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Impact of Nutrient on Metabolic Homeostasis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (27 December 2022) | Viewed by 2995

Special Issue Editors


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Guest Editor
1. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
2. Master Program in Global Health and Health Security, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan
3. Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan
4. TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 11031, Taiwan
Interests: human nutrition; functional foods; intestinal health; chronic diseases; cancers
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Special Issue Information

Dear Colleagues,

Metabolic syndrome (MetS) is a critical social problem around the world and is usually accompanied by metabolic dysfunction in humans and/or animals. Because MetS is known to be linked with metabolic disorders and the progression of diabetes, many scientists have contributed to the research on metabolic homeostasis. These fruitful results have been beneficial to health and basic research. However, numerous points remain unclear, particularly the impact of nutrients on metabolic homeostasis. Therefore, this Special Issue aims to present a collection of articles focused on the impact of nutrients on metabolic homeostasis, including the mechanisms and consequences, both in vivo and in vitro. Additionally, details of changes induced by nutrients have recently emerged for important molecules and/or signaling events in the related processes. Recently, hepatokines have been a popular topic in publications. Thus, it is important to assess the significance of these molecules in metabolic homeostasis by nutrients. You are most welcome to share findings relevant to metabolic homeostasis by nutrients that were obtained in your lab using reliable animal models and/or established cell models. 

Moreover, considering the health merits of modern therapies, this Special Issue will cover a wide variety of areas, including the repurposing of well-known nutrients, with the aim of developing useful nutrients for metabolic homeostasis from different aspects. Various forms of manuscripts are welcomed for submission to this Special Issue, including reviews and original research articles, among others. We look forward to receiving contributions from all over the world.

Dr. Juei-Tang Cheng
Prof. Dr. Jane C.-J. Chao
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic homeostasis
  • nutrients
  • endogenous hormones
  • disease model
  • human health

Published Papers (1 paper)

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Research

14 pages, 6048 KiB  
Article
Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice
by Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen and Wen-Chung Huang
Int. J. Mol. Sci. 2022, 23(9), 4687; https://doi.org/10.3390/ijms23094687 - 23 Apr 2022
Cited by 10 | Viewed by 2381
Abstract
We previously demonstrated that acacetin reduces adipogenesis in adipocytes, and decreases lipid accumulation in visceral adipocyte tissue. Here we investigated whether acacetin regulated the mechanisms of lipogenesis and inflammation in non-alcoholic fatty liver disease (NAFLD) in obese mice. Male C57BL/6 mice were fed [...] Read more.
We previously demonstrated that acacetin reduces adipogenesis in adipocytes, and decreases lipid accumulation in visceral adipocyte tissue. Here we investigated whether acacetin regulated the mechanisms of lipogenesis and inflammation in non-alcoholic fatty liver disease (NAFLD) in obese mice. Male C57BL/6 mice were fed a high-fat diet (HFD), and then administered acacetin by intraperitoneal injection. Acacetin reduced body weight and liver weight in obese mice. Acacetin-treated obese mice exhibited decreased lipid accumulation, increased glycogen accumulation, and improved hepatocyte steatosis. Acacetin regulated triglycerides and total cholesterol in the liver and serum. Acacetin decreased low-density lipoprotein and leptin concentrations, but increased high-density lipoprotein and adiponectin levels in obese mice. Acacetin effectively weakened the gene expressions of transcription factors related to lipogenesis, and promoted the expressions of genes related to lipolysis and fatty acid β-oxidation in liver. Acacetin also reduced expressions of inflammation-related cytokines in the serum and liver. Oleic acid induced lipid accumulation in murine FL83B hepatocytes, and the effects of acacetin treatment indicated that acacetin may regulate lipid metabolism through the AMPK pathway. Acacetin may protect against hepatic steatosis by modulating inflammation and AMPK expression. Full article
(This article belongs to the Special Issue Impact of Nutrient on Metabolic Homeostasis)
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