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Notch Signaling as a Versatile Regulator of Organ Physiology and Pathology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 8568

Special Issue Editors

Prof. Dr. Thimios Mitsiadis

E-Mail Website
Guest Editor
Institute of Oral Biology, Centre for Dental Medicine, Medical Faculty, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
Interests: cell fate specification; dental epithelial stem cells; dental genetics; dental pulp stem cells; dental pulp vascular biology; enamel; nerve growth factor; Notch signaling; odontogenesis; tooth innervation; Wnt signaling
Dr. Cristina Porcheri

E-Mail Website
Guest Editor
Orofacial Development and Regeneration, Institute of Oral Biology, University of Zurich, Zurich, Switzerland
Interests: cell fate specification; Notch signaling; embryonic development; stem cell biology; stem cells; imaging; niches; extracellular matrix; integrins

Special Issue Information

Dear Colleagues,

The epithelial and mesenchymal components forming the different organs and tissues of the body possess specific and specialised cell populations that ensure their physiological function in combination with well-established vascular and neuronal networks. All these features are interconnected and functionally linked by complex molecular patterning to maintain intercellular communication and specification of function. The Notch pathway is pivotal in regulating the three-dimensional organisation of organs and tissues and directly participates in cell-to-cell communication, tissue development, pathology and regeneration. Its primordial role in controlling stem cells behaviour, cell proliferation, differentiation and apoptosis makes Notch signalling one of the most fundamental elements in tissue definition. Notch plays an essential role in embryonic development directing a cascade of relevant pathways involved in fate acquisition. Alterations in the Notch signalling pathway during embryonic development generate foetal malformations in humans as a consequence of altered tissue definition. In the adult, aberrant Notch signalling is a hallmark of various diseases, such as Alagille syndrome, CADASIL, Adams–Oliver syndrome, spondylocostal dysostosis and congenital heart disorders, Hajdu–Cheney syndrome, serpentine fibula polycystic kidney syndrome, infantile myofibromatosis and lateral meningocele syndrome, and various cancers.

This Special Issue will be dedicated to compiling the role of the Notch signalling pathway in tissue development, physiology, pathology and regeneration, including studies spanning from craniofacial development and oral tissues determination.

Prof. Dr. Thimios Mitsiadis
Dr. Cristina Porcheri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Notch signaling
  • Stem cells
  • Innervation
  • Vasculature
  • Organ development
  • Tissue regeneration
  • Pathologies
  • Stem cell niches
  • Cell fates
  • Single cell analysis
  • Notch Cre mice

Published Papers (2 papers)

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Review

13 pages, 1572 KiB  
Review
Notch Signaling Regulation in Autoinflammatory Diseases
by Rossella Gratton, Paola Maura Tricarico, Adamo Pio d'Adamo, Anna Monica Bianco, Ronald Moura, Almerinda Agrelli, Lucas Brandão, Luisa Zupin and Sergio Crovella
Int. J. Mol. Sci. 2020, 21(22), 8847; https://doi.org/10.3390/ijms21228847 - 23 Nov 2020
Cited by 11 | Viewed by 2787
Abstract
Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise [...] Read more.
Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders. Full article
(This article belongs to the Special Issue Notch Signaling as a Versatile Regulator of Organ Physiology and Pathology)
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29 pages, 3959 KiB  
Review
Pleiotropic Role of Notch Signaling in Human Skin Diseases
by Rossella Gratton, Paola Maura Tricarico, Chiara Moltrasio, Ana Sofia Lima Estevão de Oliveira, Lucas Brandão, Angelo Valerio Marzano, Luisa Zupin and Sergio Crovella
Int. J. Mol. Sci. 2020, 21(12), 4214; https://doi.org/10.3390/ijms21124214 - 13 Jun 2020
Cited by 26 | Viewed by 5288
Abstract
Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either due to direct mutations or to an aberrant regulation of genes involved in the signaling [...] Read more.
Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either due to direct mutations or to an aberrant regulation of genes involved in the signaling route, might lead to both hyper- or hypo-activation of Notch signaling molecules and of target genes, ultimately inducing the onset of skin diseases. The mechanisms through which Notch contributes to the pathogenesis of skin diseases are multiple and still not fully understood. So far, Notch signaling alterations have been reported for five human skin diseases, suggesting the involvement of Notch in their pathogenesis: Hidradenitis Suppurativa, Dowling Degos Disease, Adams–Oliver Syndrome, Psoriasis and Atopic Dermatitis. In this review, we aim at describing the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in these five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies. Full article
(This article belongs to the Special Issue Notch Signaling as a Versatile Regulator of Organ Physiology and Pathology)
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