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Dr. Roberto Palacios-Ramirez

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Facultad de Medicina, Universidad de Valladolid, 45003 Valladolid, Spain
Interests: mineralocorticoid receptor in cardiometabolic diseases

Special Issue Information

Dear Colleagues,

The classical steroidal mineralocorticoid receptor antagonists (MRA) have proven to have beneficial effects not only in cardiovascular but also in many other alterations of a range of organs and tissues. The focus of this Special Issue in the International Journal of Molecular Sciences is to present novel findings regarding the potential role of the mineralocorticoid receptor in human diseases, the possibility of using mineralocorticoid receptor antagonists as a treatment, as well as the underlying mechanisms.

We invite investigators working in all fields related to the mineralocorticoid receptor to submit original research articles or reviews describing and discussing recent advancements or developments in the pathophysiology, mechanisms, and potential therapies or interventions related to the mineralocorticoid receptor.

Research areas may include, but are not limited to, the following:

Mineralocorticoid receptor activation in diseases (in vitro or in vivo);
Cellular and molecular mechanisms of mineralocorticoid-receptor-mediated diseases;
Therapies or treatments to decrease the activation of the mineralocorticoid receptor;
Mineralocorticoid receptor antagonism in human diseases.

Dr. Roberto Palacios-Ramirez
Guest Editor

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Keywords

mineralocorticoid receptor
fibrosis
inflammation

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16 pages, 24485 KiB

Open AccessArticle

First Evidence of Mineralocorticoid Receptor Gene and Protein Expression in Rat and Human Thyroid Tissues and Cell Cultures

by Jacopo Manso, Maria Chiara Pedron, Alberto Mondin, Simona Censi, Gianmaria Pennelli, Francesca Galuppini, Susi Barollo, Loris Bertazza, Claudia Maria Radu, Francesca Ghini, Paolo Simioni, Chiara Sabbadin, Filippo Ceccato, Decio Armanini and Caterina Mian

Int. J. Mol. Sci. 2024, 25(2), 754; https://doi.org/10.3390/ijms25020754 - 06 Jan 2024

Viewed by 1096

Abstract

Aldosterone (Aldo) exerts its action through binding with the mineralocorticoid receptor (MR). Clinically, a link between primary aldosteronism (PA) and thyroid diseases has been hypothesised. However, the presence and activity of MR on the thyroid have not yet been demonstrated. We investigated the gene/protein expression and activation of MR in primary thyroid cell cultures (normal rat thyroid [FRTL-5] and human papillary thyroid cancer [PTC] cell lines, BCPAP and K1) through qRT-PCR analysis, immunofluorescence, and confocal microscopy. We also studied the effects of Aldo on thyroid-specific and inflammation genes in vitro. Paired human normal and neoplastic thyroid tissues were also studied. We demonstrated both gene and protein expression and activation of MR in normal rat thyroid and human PTC lines. Incubation with Aldo induced an acute increase in IL-6 expression in both the FRTL-5 and BCPAP lines, which was antagonised by spironolactone, and an acute and late upregulation of thyroid-specific genes in FRTL-5. MR was also expressed at both gene and protein levels in normal human thyroid tissues and in PTC, with a progressive decline during neoplastic tumourigenesis, particularly in more aggressive histotypes. We present the first evidence of MR gene and protein expression in both normal and pathological thyroid cells and tissues. We have shown that MR is present and functionally activated in thyroid tissue. Binding of Aldo to MR induces the expression of inflammatory and thyroid-specific genes, and the thyroid may thus be considered a novel mineralocorticoid target tissue. Full article

(This article belongs to the Special Issue The Role of Mineralocorticoid Receptors in Human Diseases)

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