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Molecular Implications on the Use of Metallic Nanoparticles
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Molecular Implications on the Use of Metallic Nanoparticles

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Role of Xenobiotics".

Deadline for manuscript submissions: closed (20 February 2021) | Viewed by 8080

Special Issue Editors

Prof. Dr. Maria Montes

E-Mail Website
Guest Editor
Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, 33007 Oviedo, Spain
Interests: metallodrugs; nanoparticles; analytical methods; single cell analysis
Prof. Dr. Cristina Sánchez González

E-Mail Website
Guest Editor
Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Physiology, Biomedical Research Center, University of Granada, Avda del Conocimiento sn., 18100 Armilla, Granada, Spain
Interests: metals; nanoparticles; micronutrients
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of metallic nanoparticles has dramatically increased over the years. This is due to the fact that they exhibit unique physical, chemical, and biological properties at nanoscale compared to their respective species at higher scales. The main properties that are related to a relatively larger surface area to the volume, increased reactivity or stability in a chemical process, enhanced mechanical strength, etc. make them very attractive to be used in a plethora of applications. As the use of nanoparticles increases, the concerns about their spread in the environment as well as the consequences in different biological media need to be addressed. Such complex challenges require the development of new tools that permit the monitoring of these species in different compartments as well as their evolution and/or transformation together with the toxicological implications.

Prof. Dr. Maria Montes
Dr. Cristina Sánchez González
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomedical applications
  • gene delivery
  • cancer therapy
  • drug delivery
  • biomolecule detection
  • diagnosis
  • tissue engineering
  • antimicrobial resistance solutions
  • cosmetics
  • Environment
  • Biodetection and labelling
  • Biomagnetic separations
  • Food technology
  • Biotechnology and agriculture

Published Papers (1 paper)

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Review

24 pages, 2283 KiB  
Review
Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance
by Abhayraj S. Joshi, Priyanka Singh and Ivan Mijakovic
Int. J. Mol. Sci. 2020, 21(20), 7658; https://doi.org/10.3390/ijms21207658 - 16 Oct 2020
Cited by 139 | Viewed by 7568
Abstract
Many bacteria have the capability to form a three-dimensional, strongly adherent network called ‘biofilm’. Biofilms provide adherence, resourcing nutrients and offer protection to bacterial cells. They are involved in pathogenesis, disease progression and resistance to almost all classical antibiotics. The need for new [...] Read more.
Many bacteria have the capability to form a three-dimensional, strongly adherent network called ‘biofilm’. Biofilms provide adherence, resourcing nutrients and offer protection to bacterial cells. They are involved in pathogenesis, disease progression and resistance to almost all classical antibiotics. The need for new antimicrobial therapies has led to exploring applications of gold and silver nanoparticles against bacterial biofilms. These nanoparticles and their respective ions exert antimicrobial action by damaging the biofilm structure, biofilm components and hampering bacterial metabolism via various mechanisms. While exerting the antimicrobial activity, these nanoparticles approach the biofilm, penetrate it, migrate internally and interact with key components of biofilm such as polysaccharides, proteins, nucleic acids and lipids via electrostatic, hydrophobic, hydrogen-bonding, Van der Waals and ionic interactions. Few bacterial biofilms also show resistance to these nanoparticles through similar interactions. The nature of these interactions and overall antimicrobial effect depend on the physicochemical properties of biofilm and nanoparticles. Hence, study of these interactions and participating molecular players is of prime importance, with which one can modulate properties of nanoparticles to get maximal antibacterial effects against a wide spectrum of bacterial pathogens. This article provides a comprehensive review of research specifically directed to understand the molecular interactions of gold and silver nanoparticles with various bacterial biofilms. Full article
(This article belongs to the Special Issue Molecular Implications on the Use of Metallic Nanoparticles)
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