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Molecular Mechanisms of Pregnancy Complications
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Molecular Mechanisms of Pregnancy Complications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 2185

Special Issue Editor

Dr. Luis A. Silva-Lagos

E-Mail Website
Guest Editor
Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Interests: gestational diabetes mellitus; immunology; pregnancy

Special Issue Information

Dear Colleagues,

The Special Issue, titled "Molecular Mechanisms of Pregnancy Complications", aims to explore and analyze the complex biological processes and underlying molecular mechanisms that contribute to various pregnancy complications. We invite submissions that investigate the cellular and molecular causes or consequences of conditions or diseases associated with pregnancy, including gestational diabetes, preeclampsia, fetal growth restriction, and others. Our objective is to advance diagnosis, treatment, and maternal–fetal health outcomes by deepening our understanding of these disorders from both a fundamental scientific and clinical standpoint. We aim to focus on, but are not restricted to, interdisciplinary collaboration between experts in molecular biology, obstetrics, and gynecology through the acceptance of research articles, reviews, and studies that illuminate novel molecular pathways, biomarkers, and therapeutic approaches.

Dr. Luis A. Silva-Lagos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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13 pages, 1809 KiB  
Article
Substance P Concentration in Gestational Diabetes and Excessive Gestational Weight Gain and Its Impact on Neonatal Anthropometry
by Magdalena Niebrzydowska-Tatus, Aleksandra Pełech, Katarzyna Bień, Anna K. Rekowska, Aleksandra Domańska, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak and Marcin Trojnar
Int. J. Mol. Sci. 2024, 25(7), 3759; https://doi.org/10.3390/ijms25073759 - 28 Mar 2024
Viewed by 500
Abstract
Fetal programming is a process initiated by intrauterine conditions, leaving a lasting impact on the offspring’s health, whether they manifest immediately or later in life. It is believed that children born to mothers with gestational diabetes mellitus (GDM) and excessive gestational weight gain [...] Read more.
Fetal programming is a process initiated by intrauterine conditions, leaving a lasting impact on the offspring’s health, whether they manifest immediately or later in life. It is believed that children born to mothers with gestational diabetes mellitus (GDM) and excessive gestational weight gain (EGWG) may be at an increased risk of developing type 2 diabetes mellitus (T2DM) and obesity later in their adult lives. Substance P is a neurotransmitter associated with obesity development and impairment of insulin signaling. Dysregulation of substance P could lead to several pregnancy pathologies, such as preeclampsia and preterm birth. Our study aimed to compare substance P concentrations in serum and umbilical cord blood in patients with GDM, EGWG, and healthy women with a family history of gestational weight gain. Substance P levels in umbilical cord blood were significantly higher in the GDM group compared to the EGWG and control groups. Substance P levels in serum and umbilical cord blood were positively correlated in all groups and the GDM group. A very interesting direction for future research is the relationship between the concentration of substance P in newborns of diabetic mothers and the occurrence of respiratory distress syndrome as a complication of impaired surfactant synthesis. To our knowledge, it is the first study assessing substance P concentration in GDM and EGWG patients. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Pregnancy Complications)
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11 pages, 1260 KiB  
Article
Inositol-Exchange Activity in Human Primordial Placenta
by Bence Géza Kovács, Gergely Asbóth, Dorina Supák, Balázs Mészáros, Tamás Marton, Nándor Ács, Sándor Valent and Zoltán Kukor
Int. J. Mol. Sci. 2024, 25(6), 3436; https://doi.org/10.3390/ijms25063436 - 19 Mar 2024
Viewed by 458
Abstract
Human placenta is an intensively growing tissue. Phosphatidylinositol (PI) and its derivatives are part of the signaling pathway in the regulation of trophoblast cell differentiation. There are two different enzymes that take part in the direct PI synthesis: phosphatidylinositol synthase (PIS) and inositol [...] Read more.
Human placenta is an intensively growing tissue. Phosphatidylinositol (PI) and its derivatives are part of the signaling pathway in the regulation of trophoblast cell differentiation. There are two different enzymes that take part in the direct PI synthesis: phosphatidylinositol synthase (PIS) and inositol exchange enzyme (IE). The presence of PIS is known in the human placenta, but IE activity has not been documented before. In our study, we describe the physiological properties of the two enzymes in vitro. PIS and IE were studied in different Mn2+ and Mg2+ concentrations that enabled us to separate the individual enzyme activities. Enzyme activity was measured by incorporation of 3[H]inositol in human primordial placenta tissue or microsomes. Optimal PIS activity was achieved between 0.5 and 2.0 mM Mn2+ concentration, but higher concentrations inhibit enzyme activity. In the presence of Mg2+, the enzyme activity increases continuously up to a concentration of 100 mM. PIS was inhibited by nucleoside di- and tri-phosphates. PI production increases between 0.1 and 10 mM Mn2+ concentration. The incorporation of [3H]inositol into PI increased by 57% when adding stabile GTP analog. The described novel pathway of inositol synthesis may provide an additional therapeutic approach of inositol supplementation before and during pregnancy. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Pregnancy Complications)
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Review

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17 pages, 1382 KiB  
Review
The Role of Catestatin in Preeclampsia
by Michalina Bralewska, Tadeusz Pietrucha and Agata Sakowicz
Int. J. Mol. Sci. 2024, 25(5), 2461; https://doi.org/10.3390/ijms25052461 - 20 Feb 2024
Viewed by 684
Abstract
Preeclampsia (PE) is a unique pregnancy disorder affecting women across the world. It is characterized by the new onset of hypertension with coexisting end-organ damage. Although the disease has been known for centuries, its exact pathophysiology and, most importantly, its prevention remain elusive. [...] Read more.
Preeclampsia (PE) is a unique pregnancy disorder affecting women across the world. It is characterized by the new onset of hypertension with coexisting end-organ damage. Although the disease has been known for centuries, its exact pathophysiology and, most importantly, its prevention remain elusive. The basis of its associated molecular changes has been attributed to the placenta and the hormones regulating its function. One such hormone is chromogranin A (CgA). In the placenta, CgA is cleaved to form a variety of biologically active peptides, including catestatin (CST), known inter alia for its vasodilatory effects. Recent studies indicate that the CST protein level is diminished both in patients with hypertension and those with PE. Therefore, the aim of the present paper is to review the most recent and most relevant in vitro, in vivo, and clinical studies to provide an overview of the proposed impact of CST on the molecular processes of PE and to consider the possibilities for future experiments in this area. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Pregnancy Complications)
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