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Immunological and Molecular Networks in the Skin and Skin Diseases
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Immunological and Molecular Networks in the Skin and Skin Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 16 June 2024 | Viewed by 2403

Special Issue Editor

Dr. Ankit Srivastava

E-Mail Website
Guest Editor
1. Department of Dermatology, School of Medicine, Stanford University, Stanford, CA 94305, USA
2. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden
Interests: skin; skin inflammation; keratinocytes; non-coding RNAs; miRNA; skin cancers

Special Issue Information

Dear Colleagues,

Human skin is the largest immune organ, continuously exposed to pathogens and external stress. The skin combats infections, regulates body temperature, protects against UV radiation, and maintains immune as well as molecular functions. The skin is an amalgamation of epidermal, dermal, and immune cell niches. The immunological and molecular networks in the skin drive physiological/pathophysiological responses, such as skin homeostasis, skin aging, inflammatory skin diseases, wound healing, and cancers. In the last two–three decades, cutting-edge research has identified novel signaling pathways controlling normal and diseased skin functions. Notably, cellular cross-talk, supported by cytokine/chemokine networks, non-coding RNAs, and signaling proteins, mediates these immune and molecular circuits. This Special Issue highlights the immunological and molecular networks regulating normal and diseased skin.

Dr. Ankit Srivastava
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin diseases
  • skin immunology
  • skin inflammation
  • skin aging
  • skin cancers
  • cytokine/chemokine networks
  • molecular signaling pathways
  • non-coding RNAs
  • targeted therapies

Published Papers (2 papers)

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Research

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14 pages, 14007 KiB  
Article
H-VISTA Immunohistochemistry Score Is Associated with Advanced Stages in Cutaneous and Ocular Melanoma
by Andreea Cătălina Tinca, Andreea Raluca Szoke, Bianca Andreea Lazar, Emőke Andrea Szász, Alexandru Nicușor Tomuț, Adrian Horațiu Sabău, Iuliu-Gabriel Cocuz, Titiana-Cornelia Cotoi, Raluca Niculescu, Diana Maria Chiorean, Ioana Ancuța Ungureanu, Sabin Gligore Turdean and Ovidiu Simion Cotoi
Int. J. Mol. Sci. 2024, 25(8), 4335; https://doi.org/10.3390/ijms25084335 - 14 Apr 2024
Viewed by 351
Abstract
Melanoma represents a public health issue. One of the biggest goals of current research is to develop new therapeutic options for patients affected by this aggressive tumor. We conducted a retrospective study including 105 patients diagnosed with cutaneous and ocular melanoma, with stages [...] Read more.
Melanoma represents a public health issue. One of the biggest goals of current research is to develop new therapeutic options for patients affected by this aggressive tumor. We conducted a retrospective study including 105 patients diagnosed with cutaneous and ocular melanoma, with stages varying from pT1a to pT4b and pT4e, respectively, and we performed immunohistochemistry reactions with the new potential prognostic marker, VISTA (V-domain Ig suppressor of T cell activation). We quantified the expression by applying the H-score adapted for VISTA and divided the patients, based on the median value, into groups that presented high, low, and negative expression. Therefore, we obtained 65 cases with positive expression for cutaneous melanoma and 8 cases with positive expression for ocular melanoma. Forty-one cases presented high expression in cutaneous melanoma and three cases presented high expression in ocular melanoma. In cutaneous melanoma, analytic statistics showed that VISTA expression was associated with a high Breslow index, high mitotic count, high Ki67 expression, and advanced clinicopathological stage. The majority of ocular melanoma cases demonstrating a positive reaction were classified as stage pT3, whereas earlier stages showed a negative reaction. Our findings underscore a significant correlation between VISTA expression and key prognostic factors in melanoma. Looking ahead, the prospect of future randomized studies holds promise in corroborating the clinical relevance of our findings. By further elucidating the intricate relationship between VISTA expression and melanoma progression, new treatment strategies could be found, improving patient outcomes in this challenging neoplasm. Full article
(This article belongs to the Special Issue Immunological and Molecular Networks in the Skin and Skin Diseases)
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Review

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14 pages, 599 KiB  
Review
The Communication from Immune Cells to the Fibroblasts in Keloids: Implications for Immunotherapy
by Xiya Zhang, Xinfeng Wu and Dongqing Li
Int. J. Mol. Sci. 2023, 24(20), 15475; https://doi.org/10.3390/ijms242015475 - 23 Oct 2023
Viewed by 1529
Abstract
Keloids are a type of fibrotic disease characterized by excessive collagen production and extracellular matrix (ECM) deposition. The symptoms of pain and itching and frequent recurrence after treatment significantly impact the quality of life and mental health of patients. A deeper understanding of [...] Read more.
Keloids are a type of fibrotic disease characterized by excessive collagen production and extracellular matrix (ECM) deposition. The symptoms of pain and itching and frequent recurrence after treatment significantly impact the quality of life and mental health of patients. A deeper understanding of the pathogenesis of keloids is crucial for the development of an effective therapeutic approach. Fibroblasts play a central role in the pathogenesis of keloids by producing large amounts of collagen fibers. Recent evidence indicates that keloids exhibit high immune cell infiltration, and these cells secrete cytokines or growth factors to support keloid fibroblast proliferation. This article provides an update on the knowledge regarding the keloid microenvironment based on recent single-cell sequencing literature. Many inflammatory cells gathered in keloid lesions, such as macrophages, mast cells, and T lymphocytes, indicate that keloids may be an inflammatory skin disease. In this review, we focus on the communication from immune cells to the fibroblasts and the potential of immunotherapy for keloids. We hope that this review will trigger interest in investigating keloids as an inflammatory disease, which may open up new avenues for drug development by targeting immune mediators. Full article
(This article belongs to the Special Issue Immunological and Molecular Networks in the Skin and Skin Diseases)
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