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Nutrition and Metabolism in Health and Disease: From Gene to Organism 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (28 November 2023) | Viewed by 1566

Special Issue Editor


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Guest Editor
Laboratory of Physiology and Metabolism, Department of Food Safety and Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan
Interests: nutrition; phytochemicals; lipids; nuclear receptors; lipid metabolisms; inflammation; insulin resistance; hyperlipidemia; adipocytes; hepatocytes; enterocytes
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Special Issue Information

Dear Colleagues,

Food is any nutritious substance that people or animals eat or drink to maintain life and growth. It is known that nutrition has a predominant and recognizable role in health management. However, nutritional imbalance, inadequate nutrition, or default of feeding behavior can lead to metabolic disorders, leading to an alteration of the growth and even death.

In this way, finding and maintaining a nutritionally rich diet requires learning about which nutrients are healthy and which nutrients are not, how foods and nutrients impact the body, and how to use scientific resources.

Contributions to this Special Issue will provide new insights into the impact of nutrition in all animal models deciphering nutrient-mediated signaling pathways in different cell types to organs, from the detection of nutrients through their absorption and elimination to their beneficial or detrimental role in organisms.

Works that focus on studies of whole diets, nutrients (fatty acids, amino acids, carbohydrates, vitamins, etc.), or in the intake of food supplements with the aim to contribute to our knowledge about the impact of nutrition in healthy organisms, as well as nutritional or metabolic disorders or diseases are welcomed.

Prof. Dr. Nobuyuki Takahashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food nutrition
  • nutrients
  • dietary patterns 
  • dietary bioactive compounds 
  • signaling pathways 
  • feeding behavior 
  • metabolism 
  • detection, absorption, elimination 
  • biological activity 
  • health and disease

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Published Papers (1 paper)

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Research

14 pages, 2376 KiB  
Article
The Effect of Oil-Based Cannabis Extracts on Metabolic Parameters and Microbiota Composition of Mice Fed a Standard and a High-Fat Diet
by Adi Eitan, Ofer Gover, Liron Sulimani, David Meiri, Naama Shterzer, Erez Mills and Betty Schwartz
Int. J. Mol. Sci. 2024, 25(2), 1073; https://doi.org/10.3390/ijms25021073 - 16 Jan 2024
Viewed by 1187
Abstract
The prevalence of obesity and obesity-related pathologies is lower in frequent cannabis users compared to non-users. It is well established that the endocannabinoid system has an important role in the development of obesity. We recently demonstrated that prolonged oral consumption of purified Δ-9 [...] Read more.
The prevalence of obesity and obesity-related pathologies is lower in frequent cannabis users compared to non-users. It is well established that the endocannabinoid system has an important role in the development of obesity. We recently demonstrated that prolonged oral consumption of purified Δ-9 Tetrahydrocannabinol (THC), but not of cannabidiol (CBD), ameliorates diet-induced obesity and improves obesity-related metabolic complications in a high-fat diet mouse model. However, the effect of commercially available medical cannabis oils that contain numerous additional active molecules has not been examined. We tested herein the effects of THC- and CBD-enriched medical cannabis oils on obesity parameters and the gut microbiota composition of C57BL/6 male mice fed with either a high-fat or standard diet. We also assessed the levels of prominent endocannabinoids and endocannabinoid-like lipid mediators in the liver. THC-enriched extract prevented weight gain by a high-fat diet and attenuated diet-induced liver steatosis concomitantly with reduced levels of the lipid mediators palmitoyl ethanolamide (PEA) and docosahexaenoyl ethanolamide (DHEA) in the liver. In contrast, CBD-enriched extract had no effect on weight gain, but, on the contrary, it even exacerbated liver steatosis. An analysis of the gut microbiota revealed that mainly time but not treatment exerted a strong effect on gut microbiota alterations. From our data, we conclude that THC-enriched cannabis oil where THC is the main constituent exerts the optimal anti-obesity effects. Full article
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