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Toxicity of Nanoparticles

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 926

Special Issue Editor


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Guest Editor
1. Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
2. World Institute for Family Health, University of Kalisz, Nowy Swiat 4, 62-800 Kalisz, Poland
Interests: nanotoxicology; impact of nanoparticles on cancer; pesticides toxicity; environmental health

Special Issue Information

Dear Colleagues,

The rapid expansion of nanotechnologies promises to have significant beneficial impacts on society, yet there is increasing concern that exposure to nanoparticles (NPs) will have a negative impact on both human and environmental health. Nanoparticles can easily enter the human body and cross all intrinsic barriers, making them very useful as drug delivery vectors; on the other hand, NPs may interact with biological systems and induce potentially negative effects. Presently, there is increasing concern about the detrimental health effects due to NP exposure. Nanoparticles have been reported to induce oxidative stress, DNA damage, inflammation, and many other adverse effects that are known to be crucial for the development of lifestyle diseases.

Studies have shown that the toxic effects of NPs are mainly determined by several factors, such as physicochemical properties, dose, exposure pathways, and duration. The unique physicochemical properties of NPs confer not only promising biological effects but also pose unexpected toxic threats to the human body at the same time. The chronic exposure to low doses of noxious chemicals mainly of anthropogenic origin is inevitable; therefore, it is important to expand our knowledge about the mechanisms underlying the adverse effects of nanoparticles. Based on our current knowledge, it is challenging to elucidate the exact mechanisms of NP toxicity.

This Special Issue focuses on the in vitro and in vivo interactions of nanomaterials with biological systems at different levels of organization. We welcome both experimental works and review papers regarding the negative effects of nanoparticles on the molecular and cellular levels, on tissues and organs, and on whole organisms. We also welcome studies on animal model systems and the environmental and occupational exposure of humans to nanoparticles.

It is my pleasure to invite manuscript submissions for this Special Issue.

This Special Issue is supervised by Prof. Dr. Lucyna Kapka-Skrzypczak and assisted by our Topical Advisory Panel Member Dr. Magdalena Matysiak-Kucharek (Institute of Rural Health).

Prof. Dr. Lucyna Kapka-Skrzypczak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanotoxicity
  • exposure to nanoparticles
  • health effects
  • biological effects
  • oxidative stress
  • environmental health

Published Papers (1 paper)

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Review

40 pages, 1445 KiB  
Review
Gold Nanoparticles (AuNPs)—Toxicity, Safety and Green Synthesis: A Critical Review
by Łukasz Niżnik, Maciej Noga, Damian Kobylarz, Adrian Frydrych, Alicja Krośniak, Lucyna Kapka-Skrzypczak and Kamil Jurowski
Int. J. Mol. Sci. 2024, 25(7), 4057; https://doi.org/10.3390/ijms25074057 - 05 Apr 2024
Viewed by 669
Abstract
In recent years, the extensive exploration of Gold Nanoparticles (AuNPs) has captivated the scientific community due to their versatile applications across various industries. With sizes typically ranging from 1 to 100 nm, AuNPs have emerged as promising entities for innovative technologies. This article [...] Read more.
In recent years, the extensive exploration of Gold Nanoparticles (AuNPs) has captivated the scientific community due to their versatile applications across various industries. With sizes typically ranging from 1 to 100 nm, AuNPs have emerged as promising entities for innovative technologies. This article comprehensively reviews recent advancements in AuNPs research, encompassing synthesis methodologies, diverse applications, and crucial insights into their toxicological profiles. Synthesis techniques for AuNPs span physical, chemical, and biological routes, focusing on eco-friendly “green synthesis” approaches. A critical examination of physical and chemical methods reveals their limitations, including high costs and the potential toxicity associated with using chemicals. Moreover, this article investigates the biosafety implications of AuNPs, shedding light on their potential toxic effects on cellular, tissue, and organ levels. By synthesizing key findings, this review underscores the pressing need for a thorough understanding of AuNPs toxicities, providing essential insights for safety assessment and advancing green toxicology principles. Full article
(This article belongs to the Special Issue Toxicity of Nanoparticles)
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