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Immunotherapy: A New Perspective in Cancer Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 900

Special Issue Editor


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Guest Editor
Laboratory for Cancer Research, Department of Immunology and Medical Genetics, University of Split School of Medicine, 21000 Split, Croatia
Interests: DNA repair; DNA replication; immunotherapy; cancer treatment; oncology

Special Issue Information

Dear Colleagues,

The special issue of The International Journal of Molecular Sciences, entitled “Immunotherapy: A New Perspective in Cancer Treatment” encompasses an exploration of the evolving landscape of cancer treatment through the lens of immunotherapy. This comprehensive examination will delve into the latest breakthroughs, emerging technologies, and innovative approaches that are revolutionizing the field of oncology.

Within this scope, we will investigate the principles of immunotherapy, including its mechanisms of action and the different modalities such as checkpoint inhibitors, CAR-T cell therapy, and therapeutic vaccines. The discussion will encompass not only the scientific and medical aspects but also the practical considerations, such as the availability, accessibility, and affordability of these treatments.

Additionally, this exploration will highlight the remarkable success stories and clinical trials that have demonstrated the potential of immunotherapy in treating a wide range of cancer types. It will also address the challenges, limitations, and ongoing research aimed at enhancing the effectiveness of immunotherapy.

Furthermore, the scope extends to the ethical, economic, and societal implications of immunotherapy, including its impact on healthcare systems, patient quality of life, and the role of patient advocacy in driving research and accessibility.

Ultimately, this comprehensive examination will provide a holistic view of the cutting-edge advancements in immunotherapy and how they are reshaping the future of cancer treatment.

Prof. Dr. Ivana Marinović-Terzić
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunotherapy
  • cancer treatment
  • breakthroughs
  • oncology
  • checkpoint inhibitors
  • CAR-T cell therapy
  • therapeutic vaccines
  • clinical trials
  • accessible healthcare

Published Papers (1 paper)

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Research

16 pages, 4296 KiB  
Article
Near-Infrared Photoimmunotherapy Using a Protein Mimetic for EGFR-Positive Salivary Gland Cancer
by Haruka Yamaguchi, Takamasa Suzuki, Yasuo Okada, Junya Ono, Hiroto Sano, Akiko Banba, Hideyuki Sakata, Akihiro Ishikawa and Takao Morita
Int. J. Mol. Sci. 2024, 25(6), 3233; https://doi.org/10.3390/ijms25063233 - 12 Mar 2024
Viewed by 573
Abstract
Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer therapy based on a monoclonal antibody (mAb) conjugated to a photosensitizer (IR700Dye). The conjugate can be activated by near-infrared light irradiation, causing necrotic cell death with high selectivity. In this study, we investigated NIR-PIT using a [...] Read more.
Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer therapy based on a monoclonal antibody (mAb) conjugated to a photosensitizer (IR700Dye). The conjugate can be activated by near-infrared light irradiation, causing necrotic cell death with high selectivity. In this study, we investigated NIR-PIT using a small protein mimetic (6–7 kDa, Affibody) which has more rapid clearance and better tissue penetration than mAbs for epidermal growth factor receptor (EGFR)-positive salivary gland cancer (SGC). The level of EGFR expression was examined in vitro using immunocytochemistry and Western blotting. Cell viability was analyzed using the alamarBlue assay. In vivo, the volume of EGFR-positive tumors treated with NIR-PIT using the EGFR Affibody–IR700Dye conjugate was followed for 43 days. It was found that NIR-PIT using the EGFR Affibody–IR700Dye conjugate induced the selective destruction of EGFR-positive SGC cells and restricted the progression of EGFR-positive tumors. We expect that NIR-PIT using the EGFR Affibody–IR700Dye conjugate can efficiently treat EGFR-positive SGC and preserve normal salivary function. Full article
(This article belongs to the Special Issue Immunotherapy: A New Perspective in Cancer Treatment)
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