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Molecular Mechanisms of Primary Graft Dysfunction and Acute Rejection in Solid Organ Transplantation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 83

Special Issue Editor

Feinberg School of Medicine, Northwestern University, Simpson Querrey 5-407, 303 E Superior Street, Chicago, IL 60611, USA
Interests: lung; transplant; monocytes; neutrophils; primary graft dysfunction; sodium transport; Toll-like receptors; signaling transduction
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Special Issue Information

Dear Colleagues,

Solid organ transplantation is a lifesaving therapeutic strategy for numerous end-stage organ failures. Organ rejection is the most critical problem affecting the long-term survival of allografts, and it is determined by the activation of a host’s innate and adaptive immune systems. The initial immune response leading to primary graft dysfunction (PGD) after a transplant is a consequence of the ischemia and reperfusion injury (IRI) to which grafts are exposed during procurement and implantation. Besides IRI, allo-antigen (major histocompatibility complex, MHC) recognition by immune cells also plays a role in acute rejection.

This Special Issue is focused on the mechanisms involved in the development of PGD and acute rejection after IRI and allo-antigen recognition, including, but not limited to, IRI-induced changes in the cellular microenvironment, intracellular metabolic reprograming, cellular stress and death pathways, damage-associated molecular pattern (DAMP) recognition, recognition of allo-antigens by immune cells, and clinical studies with biomolecular experiments.

Dr. Emilia Lecuona
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • transplant
  • graft dysfunction
  • ischemia–reperfusion injury
  • DAMPs
  • immune cells
  • allo-antigens
  • acute rejection
  • metabolism
  • cell death
  • MHC
  • PRRs

Published Papers

This special issue is now open for submission.
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