Molecular Mechanisms of Primary Graft Dysfunction and Acute Rejection in Solid Organ Transplantation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 119
Special Issue Editor
Interests: lung; transplant; monocytes; neutrophils; primary graft dysfunction; sodium transport; Toll-like receptors; signaling transduction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Solid organ transplantation is a lifesaving therapeutic strategy for numerous end-stage organ failures. Organ rejection is the most critical problem affecting the long-term survival of allografts, and it is determined by the activation of a host’s innate and adaptive immune systems. The initial immune response leading to primary graft dysfunction (PGD) after a transplant is a consequence of the ischemia and reperfusion injury (IRI) to which grafts are exposed during procurement and implantation. Besides IRI, allo-antigen (major histocompatibility complex, MHC) recognition by immune cells also plays a role in acute rejection.
This Special Issue is focused on the mechanisms involved in the development of PGD and acute rejection after IRI and allo-antigen recognition, including, but not limited to, IRI-induced changes in the cellular microenvironment, intracellular metabolic reprograming, cellular stress and death pathways, damage-associated molecular pattern (DAMP) recognition, recognition of allo-antigens by immune cells, and clinical studies with biomolecular experiments.
Dr. Emilia Lecuona
Guest Editor
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Keywords
- transplant
- graft dysfunction
- ischemia–reperfusion injury
- DAMPs
- immune cells
- allo-antigens
- acute rejection
- metabolism
- cell death
- MHC
- PRRs
