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State-of-the-Art Molecular Immunology in USA

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2697

Special Issue Editors


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Collection Editor
Department of Pathology, Prostate Cancer Center of Excellence, MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226​, USA
Interests: prostate cancer; tumor immunology; immunotherapy; tumor microenvironment

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Collection Editor
Feinberg School of Medicine, Northwestern University, Simpson Querrey 5-407, 303 E Superior Street, Chicago, IL 60611, USA
Interests: lung; transplant; monocytes; neutrophils; primary graft dysfunction; sodium transport; Toll-like receptors; signaling transduction
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Special Issue Information

Dear Colleagues,

A large number of research teams in the USA from different institutions and universities are working together to study the molecular mechanisms of immunity, immunogenetics and/or immunopathogenesis. This Topical Collection of the International Journal of Molecular Sciences (IJMS) aims to rapidly publish original contributions addressing questions of importance in immunology and related fields from the USA. We welcome manuscripts conveying novel experimental findings that may advance our understanding of the molecular mechanisms of immunity, immunogenetics and/or immunopathogenesis. Manuscripts reporting on the development or testing of novel therapeutics that target molecular mechanisms are likewise sought. 

Dr. Dev Karan
Dr. Emilia Lecuona
Collection Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (1 paper)

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Research

51 pages, 10261 KiB  
Article
T Cell Receptor Sequences Amplified during Severe COVID-19 and Multisystem Inflammatory Syndrome in Children Mimic SARS-CoV-2, Its Bacterial Co-Infections and Host Autoantigens
by Robert Root-Bernstein, Elizabeth Churchill and Shelby Oliverio
Int. J. Mol. Sci. 2023, 24(2), 1335; https://doi.org/10.3390/ijms24021335 - 10 Jan 2023
Cited by 4 | Viewed by 2036
Abstract
Published hypervariable region V-beta T cell receptor (TCR) sequences were collected from people with severe COVID-19 characterized by having various autoimmune complications, including blood coagulopathies and cardiac autoimmunity, as well as from patients diagnosed with the Kawasaki disease (KD)-like multisystem inflammatory syndrome in [...] Read more.
Published hypervariable region V-beta T cell receptor (TCR) sequences were collected from people with severe COVID-19 characterized by having various autoimmune complications, including blood coagulopathies and cardiac autoimmunity, as well as from patients diagnosed with the Kawasaki disease (KD)-like multisystem inflammatory syndrome in children (MIS-C). These were compared with comparable published v-beta TCR sequences from people diagnosed with KD and from healthy individuals. Since TCR V-beta sequences are supposed to be complementary to antigens that induce clonal expansion, it was surprising that only a quarter of the TCR sequences derived from severe COVID-19 and MIS-C patients mimicked SARS-CoV-2 proteins. Thirty percent of the KD-derived TCR mimicked coronaviruses other than SARS-CoV-2. In contrast, only three percent of the TCR sequences from healthy individuals and those diagnosed with autoimmune myocarditis displayed similarities to any coronavirus. In each disease, significant increases were found in the amount of TCRs from healthy individuals mimicking specific bacterial co-infections (especially Enterococcus faecium, Staphylococcal and Streptococcal antigens) and host autoantigens targeted by autoimmune diseases (especially myosin, collagen, phospholipid-associated proteins, and blood coagulation proteins). Theoretical explanations for these surprising observations and implications to unravel the causes of autoimmune diseases are explored. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Immunology in USA)
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