Neurospecific Substances as Biomarkers of Central Nervous System in Periphery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 2013
Special Issue Editor
Interests: neuroscience; neuropharmacology; neurodegenerative disorders; traumatic brain injury; animal models; behavior; neurogenomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
we are pleased to announce a Special Issue for International Journal of Molecular Sciences entitled “Neurospecific Substances as Biomarkers of Central Nervous System in Periphery”.
The identification of reliable biomarkers is a key approach to the early diagnosis of pathological processes in the organism. Human brain state is usually estimated by brain-specific substances in peripheral tissues that are easily accessible for research, i.e., blood, urine, saliva, and, less often, cerebrospinal fluid. This approach also contributes to a better understanding of normal neurophysiology and pathogenetic mechanisms of neuropsychiatric diseases. However, due to the blood-brain barrier and a number of other reasons, such concordance or associations may be weak or completely absent. The relation between the concentration of neurospecific molecules in the periphery and their content in the brain remains unknown for most analytes. Recent advances in technologies of in vivo analysis (i.e., metabolomic analyses, neuroimaging (MRS, PET, SPECT), and blood assays for exosomes of brain origin) allow expecting a breakthrough in the field soon. This Special Issue is meant to highlight recent progress in the topic. We invite all types of articles providing new insights about brain-specific biomarkers in peripheral tissues, with a focus on human studies. Although human findings would go in priority, animal and translational studies presenting essential new knowledge related to the topic are also welcome.
Dr. Maria Tikhonova
Guest Editor
Manuscript Submission Information
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Keywords
- human
- brain
- plasma
- serum
- blood cells
- concordance
- post-mortem
- neuroimaging
- immuno-assay
- blood-brain barrier
- exosomes
