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Nutrition and Cancer: Molecular Mechanisms between Nutrition and Cancer Etiology, Prevention, and Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 8530

Special Issue Editors

Dr. Constantinos Giaginis

E-Mail Website
Guest Editor
Department of Food Science & Nutrition, University of the Aegean, Lemnos, Greece
Interests: human nutrition; cancer; cancer treatment; cancer diagnostics; wellness; public health; nutritional pathophysiology; nutritional epidemiology; nutritional assessment; cancer biomarkers
Prof. Dr. Stamatios E. Theocharis

E-Mail Website
Guest Editor
First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: cancer pathology; cancer biomarker; cancer diagnosis; cancer prognosis; nutritional intervention in cancer clinical and experimental studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

This Special Issue focuses on the effects and the underlined molecular mechanisms of nutrition and cancer etiology, prevention, and the treatment of cancer, including epidemiological effects. This Special Issue also focuses on the molecular mechanisms underlining etiological factors through clinical and experimental research. Original research as well as review articles on the molecular mechanisms related to the nutritional assessment and management of cancer patients in association with disease progression, prognosis and cotreatment with standard therapy and a quality-of-life assessment are welcome. Cancer prevention approaches including public health recommendations and policies, healthy dietary patterns, and individual foods or naturally occurring bioactive compounds with anticancer activity are also welcome.

Topics of this Special Issue include, but are not limited to:

  • Nutritional assessment and management of cancer patients;
  • Etiological factors and clinical and experimental research, carcinogenesis, and epidemiology in cancer;
  • Nutrition and disease progression, prognosis and cotreatment with standard therapy and a quality-of-life assessment of cancer patients;
  • Nutritional prevention with the use of clinical and experimental research.

We look forward to receiving your contributions.

Dr. Costantinos Giaginis
Prof. Dr. Stamatios E. Theocharis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • etiological factors
  • cancer nutritional intervention clinical studies
  • cancer intervention experimental studies
  • nutritional treatment of cancer patients
  • nutritional management of cancer patients
  • cancer biomarkers and nutrition
  • quality of life of cancer patients
  • dietary patterns with anticancer activity
  • naturally occurring bioactive compounds with anticancer properties
  • molecular oncology

Published Papers (3 papers)

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Review

17 pages, 1375 KiB  
Review
Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery
by Maria Spanoudaki, Sofia Stoumpou, Sousana K. Papadopoulou, Dimitra Karafyllaki, Evangelos Solovos, Konstantinos Papadopoulos, Anastasia Giannakoula and Constantinos Giaginis
Int. J. Mol. Sci. 2023, 24(18), 14270; https://doi.org/10.3390/ijms241814270 - 19 Sep 2023
Viewed by 2284
Abstract
Cancer rates are increasing, and cancer is one of the main causes of death worldwide. Amygdalin, also known as vitamin B17 (and laetrile, a synthetic compound), is a cyanogenic glycoside compound that is mainly found in the kernels and pulps of fruits. This [...] Read more.
Cancer rates are increasing, and cancer is one of the main causes of death worldwide. Amygdalin, also known as vitamin B17 (and laetrile, a synthetic compound), is a cyanogenic glycoside compound that is mainly found in the kernels and pulps of fruits. This compound has been proposed for decades as a promising naturally occurring substance which may provide anticancer effects. This is a comprehensive review which critically summarizes and scrutinizes the available studies exploring the anticancer effect of amygdalin, highlighting its potential anticancer molecular mechanisms as well as the need for a nontoxic formulation of this substance. In-depth research was performed using the most accurate scientific databases, e.g., PubMed, Cochrane, Embase, Medline, Scopus, and Web of Science, applying effective, characteristic, and relevant keywords. There are several pieces of evidence to support the idea that amygdalin can exert anticancer effects against lung, breast, prostate, colorectal, cervical, and gastrointestinal cancers. Amygdalin has been reported to induce apoptosis of cancer cells, inhibiting cancer cells’ proliferation and slowing down tumor metastatic spread. However, only a few studies have been performed in in vivo animal models, while clinical studies remain even more scarce. The current evidence cannot support a recommendation of the use of nutritional supplements with amygdalin due to its cyano-moiety which exerts adverse side effects. Preliminary data have shown that the use of nanoparticles may be a promising alternative to enhance the anticancer effects of amygdalin while simultaneously reducing its adverse side effects. Amygdalin seems to be a promising naturally occurring agent against cancer disease development and progression. However, there is a strong demand for in vivo animal studies as well as human clinical studies to explore the potential prevention and/or treatment efficiency of amygdalin against cancer. Moreover, amygdalin could be used as a lead compound by effectively applying recent developments in drug discovery processes. Full article
(This article belongs to the Special Issue Nutrition and Cancer: Molecular Mechanisms between Nutrition and Cancer Etiology, Prevention, and Treatment)
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15 pages, 754 KiB  
Review
Can Dietary Actives Affect miRNAs and Alter the Course or Prevent Colorectal Cancer?
by Monika Prendecka-Wróbel, Dominika Pigoń-Zając, Daria Sondej, Karolina Grzywna, Katarzyna Kamińska, Mariusz Szuta and Teresa Małecka-Massalska
Int. J. Mol. Sci. 2023, 24(12), 10142; https://doi.org/10.3390/ijms241210142 - 14 Jun 2023
Cited by 1 | Viewed by 1345
Abstract
Colorectal cancer is a diet-related cancer. There is much research into the effects of nutrients on the prevention, modulation, and treatment of colorectal cancer. Researchers are trying to find a correlation between epidemiological observations indicating certain dietary components as the originator in the [...] Read more.
Colorectal cancer is a diet-related cancer. There is much research into the effects of nutrients on the prevention, modulation, and treatment of colorectal cancer. Researchers are trying to find a correlation between epidemiological observations indicating certain dietary components as the originator in the process of developing colorectal cancer, such as a diet rich in saturated animal fats, and dietary components that could eliminate the impact of harmful elements of the daily nutritional routine, i.e., substances such as polyunsaturated fatty acids, curcumin, or resveratrol. Nevertheless, it is very important to understand the mechanisms underlying how food works on cancer cells. In this case, microRNA (miRNA) seems to be a very significant research target. MiRNAs participate in many biological processes connected to carcinogenesis, progression, and metastasis. However, this is a field with development prospects ahead. In this paper, we review the most significant and well-studied food ingredients and their effects on various miRNAs involved in colorectal cancer. Full article
(This article belongs to the Special Issue Nutrition and Cancer: Molecular Mechanisms between Nutrition and Cancer Etiology, Prevention, and Treatment)
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12 pages, 615 KiB  
Review
The Role of Bitter Melon in Breast and Gynecological Cancer Prevention and Therapy
by Iason Psilopatis, Kleio Vrettou, Constantinos Giaginis and Stamatios Theocharis
Int. J. Mol. Sci. 2023, 24(10), 8918; https://doi.org/10.3390/ijms24108918 - 17 May 2023
Cited by 2 | Viewed by 4361
Abstract
Phytotherapy has long represented a widely accepted treatment alternative to conventional therapy. Bitter melon is a vine with potent antitumor effects against numerous cancer entities. To date, no review article has, however, been published on the role of bitter melon in breast and [...] Read more.
Phytotherapy has long represented a widely accepted treatment alternative to conventional therapy. Bitter melon is a vine with potent antitumor effects against numerous cancer entities. To date, no review article has, however, been published on the role of bitter melon in breast and gynecological cancer prevention and therapy. The current work constitutes the most comprehensive, up-to-date review of the literature, which highlights the promising anticancer effects of bitter melon on breast, ovarian, and cervical cancer cells and discusses future research recommendations. Full article
(This article belongs to the Special Issue Nutrition and Cancer: Molecular Mechanisms between Nutrition and Cancer Etiology, Prevention, and Treatment)
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