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Bioinspired Functional Materials for Biomedical Applications 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 2473

Special Issue Editors


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Guest Editor
Institute for Organic Synthesis and Photoractivity (IOSF), National Research Council (CNR), 40129 Bologna, Italy
Interests: epigenetics; cellular and molecular biology; cancer; drug delivery systems; biodrugs
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute for Organic Synthesis and Photoractivity (IOSF), National Research Council (CNR), 40129 Bologna, Italy
Interests: chemical biology; Raman and IR spectroscopy; biomolecules; hyperspectral imaging

E-Mail Website
Guest Editor
Institute for Organic Synthesis and Photoractivity (IOSF), National Research Council (CNR), 40129 Bologna, Italy
Interests: organic electrochemistry; conducting polymer biointerfaces; chemical sciences; material sciences

Special Issue Information

Dear Colleagues,

Biomaterials are rapidly becoming one of the most influential and innovative hot topics of research in the 21st century. The biomaterial age ushers a completely new technological paradigm that favors the development of sustainable materials—a bioinspired perspective based on the control and reproduction of the principles of biological materials using their own components. The intrinsic design intelligence in biomaterials is today a recurrent source of inspiration in material sciences. Materials that reproduce those designs with native components are configured in the same way they are organized in nature; the result is a material of outstanding mechanical and functional properties beyond those of its constituents.

The design and development of multifunctional smart biomaterials that are compatible to human physiology is crucial to achieve the required biological function with a reduced negative biological response. Several biosensors, biomimetic drug delivery systems and medical bioimplants have been tested to boost life expectancy and improve quality of life.

While significant progress has been made in technology and the methods for the synthesis and self-assembly of bioinspired functional materials, their use for biomedical applications is still at its infancy with significant future impact.

In this Special Issue, we will provide an overview of the major challenges and fundamental discoveries regarding bioinspired functional materials, whose structure, properties or function mimic those of natural materials or living matter. Particular attention will be devoted to the efforts under way to exploit the functional properties of new bioderived, biomimetic, biodegradable and biocompatible materials.

Original research and reviews with a strong focus on newer and challenging products are welcome, with particular emphasis on, but not limited to, functionalized bioderived sensors for theranostics applications, biomimetic drug delivery systems for next-generation target therapy, biocompatible materials for biomechatronic artificial organs and prosthetics, bioscaffold and tissue-like materials for regenerative medicine applications.

Fabio Testi (fabio.testi@isof.cnr.it) from National Research Council (CNR) will assist in managing this Special Issue.

Prof. Dr. Caterina Cinti
Dr. Armida Torreggiani
Dr. Alberto Zanelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials for biomedical applications
  • bioinspired materials
  • bioderived biosensors
  • biomimetic drug delivery systems
  • biomechanotronics
  • artificial organs
  • prosthetics
  • tissue-like materials
  • bioscaffolds

Published Papers (1 paper)

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Research

14 pages, 8213 KiB  
Article
Development of Gelatin Methacryloyl/Sodium Alginate Interpenetrating Polymer Network Hydrogels for Bone Regeneration by Activating the Wnt/β-Catenin Signaling Pathway via Lithium Release
by Chen Ma, Yu-Kyoung Kim, Min-Ho Lee and Yong-Seok Jang
Int. J. Mol. Sci. 2023, 24(17), 13613; https://doi.org/10.3390/ijms241713613 - 2 Sep 2023
Cited by 1 | Viewed by 1722
Abstract
Hydrogels have gained significant attention as biomaterials due to their remarkable properties resembling those of the extracellular matrix (ECM). In the present investigation, we successfully synthesized interpenetrating polymer network (IPN) hydrogels using gelatin methacryloyl (GelMA) and sodium alginate (SA), incorporating various concentrations of [...] Read more.
Hydrogels have gained significant attention as biomaterials due to their remarkable properties resembling those of the extracellular matrix (ECM). In the present investigation, we successfully synthesized interpenetrating polymer network (IPN) hydrogels using gelatin methacryloyl (GelMA) and sodium alginate (SA), incorporating various concentrations of lithium chloride (LiCl; 0, 5, and 10 mM), aiming to develop a hydrogel scaffold for bone regeneration. Notably, the compressive modulus of the IPN hydrogels remained largely unaffected upon the inclusion of LiCl. However, the hydrogel with the high concentration of LiCl exhibited reduced fragmentation after compression testing. Intriguingly, we observed a significant improvement in cellular biocompatibility, primarily attributed to activation of the Wnt/β-catenin signaling pathway induced by LiCl. Subsequently, we evaluated the efficacy of the newly developed IPN-Li hydrogels in a rat cranial defect model and found that they substantially enhanced bone regeneration. Nevertheless, it is important to note that the introduction of high concentrations of LiCl did not significantly promote osteogenesis. This outcome can be attributed to the excessive release of Li+ ions into the extracellular matrix, hindering the desired effect. Overall, the IPN-Li hydrogel developed in this study holds great promise as a biodegradable material for bone regeneration applications. Full article
(This article belongs to the Special Issue Bioinspired Functional Materials for Biomedical Applications 2.0)
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