Epilepsy: Molecular Mechanisms and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 24 May 2024 | Viewed by 4285
Special Issue Editors
Interests: neuropharmacology; behavioral neuroscience; epilepsy; depression; anxiety, natural compounds
Special Issues, Collections and Topics in MDPI journals
Interests: epilepsy; neuropharmacology; zebrafish; behavioral neuroscience; genetic models; screening; deep phenotyping
Special Issues, Collections and Topics in MDPI journals
Interests: neurobiology; pharmacology; stress; psychiatric disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epilepsy is a severe and chronic disorder of the central nervous system that affects about 1% of the population worldwide. It is characterized by recurrent and spontaneous seizures which result from excessive electrical discharges of neurons in various parts of the brain. Seizures might manifest as short periods of unconsciousness as well as disturbances in sensory, motor, or vegetative functions, and might also prolong to status epilepticus. Although pharmacotherapy is the main treatment for epilepsy, the currently available antiseizure drugs do not cure epilepsy but only allow a reduction in the intensity and/or frequency of epileptic seizures. Moreover, anticonvulsant medication often provokes numerous side effects.
The aim of this Special Issue on “Epilepsy: Molecular Mechanisms and Therapies” is to collect innovative research focused on various aspects of the molecular mechanisms of epileptic disorders and epileptogenesis. We are also interested in papers that present some new therapy possibilities for epilepsy and comorbid diseases. Preclinical studies from in vitro tests and animal models as well as clinical studies will be considered.
We look forward to your manuscript submission in the form of original papers, reviews and short communications.
Dr. Dorota Teresa Nieoczym
Dr. Kinga Gawel
Dr. Agnieszka Zelek-Molik
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
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epilepsy
- seizures
- epileptogenesis
- anticonvulsant drugs
- ion channels
- neurotransmitters
- molecular mechanisms
- epilepsy/seizure models
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title：Mass spectrometry as a quantitative proteomic analysis tool for the search for temporal lobe epilepsy biomarkers: a systematic review
Abstract:
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults. Tissue reorganization at the site of the epileptogenic focus is accompanied by changes in the expression patterns of protein molecules. The study of mRNA and its corresponding proteins is crucial for understanding the pathogenesis of the disease. Protein expression profiles do not always directly correlate with the levels of their transcripts; therefore, it is protein profiling that is no less important for understanding the molecular mechanisms and biological processes of TLE. The study and annotation of proteins that are statistically significantly different in patients with TLE is an approach to search for biomarkers of this disease, various stages of its development, as well as a method for searching for specific targets for the development of a further therapeutic strategy.
For this study, a systematic search for publications in databases such as PubMed, Springer, Web of Science, Scopus, ScienceDirect, and MDPI was carried out. The following keywords were used: temporal lobe epilepsy, proteomic, biomarkers, mass-spectrometry, protein expression.
Publications from 2003 to the present have been analyzed. Studies of brain tissues, experimental models of epilepsy, as well as biological fluids were analyzed. For each of the groups, aberrantly expressed proteins found in various studies were isolated. Most of the studies omitted important characteristics of the studied patients, such as: duration of illness, type and response to therapy, gender, etc. Proteins that overlap across different tissue types and different studies have been highlighted: DPYSL, PARK7, GFAP, SYT1, C4B, PRDX6, GAPDH, STMN1, APOE, NME1, and others.The most common biological processes for them were Positive regulation of neurofibrillary tangle assembly, regulation of amyloid fibril formation, Lipoprotein catabolic process, Positive regulation of vesicle fusion, Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, Removal of superoxide radicals, Axon extension, Regulation of actin filament depolymerization. MS-based proteomic profiling for a relevant study must accept a number of limitations, the most important of which is the need to compare different types of neurological and, in particular, epileptic disorders. Such a criterion could increase the specificity of the search work and, in the future, lead to the discovery of biomarkers for a particular disease.
Keywords: temporal lobe epilepsy, proteomic, biomarkers, mass-spectrometry, protein expression.
