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Potentialities and Challenges of Bio-Inspired Delivery Systems
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Potentialities and Challenges of Bio-Inspired Delivery Systems

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 8096

Special Issue Editors

Prof. Dr. Andrey Zamyatnin

E-Mail Website
Guest Editor
1. Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia
2. Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia
3. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia
4. Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7X, UK
Interests: programmed cell death; protein processing; intracellular communications; virus-cell interactions; regulation of gene expression; RNAi; oxidative stress; aging; neurodegeneration; ophthalmology; cancer; regenerative medicine; personalized medicine; molecular markers; biotechnology; drug design; novel drug candidates; plant biology; virology
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandro Parodi

E-Mail Website
Guest Editor
Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia
Interests: medical nanotechnology; delivery systems; nano drug delivery; protease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in drug delivery and nanomedicine allowed for the generation of carriers with intrinsic biologic properties to increase their bio-compatibility, immune tolerance and targeting of sick tissues. Biomimetic delivery platforms can be generated from basically any kind of cellular phenotype recapitulating the surface properties and the biological identity of the cell source. Erythrocyte ghosts, leukosomes, and platelet-derived particles represent only a few examples of these technologies. This class of carriers pairs with new discoveries in the generation of exosomes and cellular vesicles that can be loaded with different kinds of payloads and were recently tested in clinics. This Special Issue aims at collecting original works and reviews dedicated to complex biological carriers, including the work necessary to synthesize, purify and characterize them as well as their application and potential side effects (i.e., immunological response) in the medical field.

Prof. Dr. Andrey Zamyatnin
Dr. Alessandro Parodi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • nanomedicine
  • biomimetic delivery
  • biological carriers

Published Papers (4 papers)

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Research

15 pages, 2266 KiB  
Article
Upconversion Nanoparticles Intercalated in Large Polymer Micelles for Tumor Imaging and Chemo/Photothermal Therapy
by Polina A. Demina, Kirill V. Khaydukov, Gulalek Babayeva, Pavel O. Varaksa, Alexandra V. Atanova, Maxim E. Stepanov, Maria E. Nikolaeva, Ivan V. Krylov, Irina I. Evstratova, Vadim S. Pokrovsky, Vyacheslav S. Zhigarkov, Roman A. Akasov, Tatiana V. Egorova, Evgeny V. Khaydukov and Alla N. Generalova
Int. J. Mol. Sci. 2023, 24(13), 10574; https://doi.org/10.3390/ijms241310574 - 24 Jun 2023
Cited by 2 | Viewed by 1636
Abstract
Frontiers in theranostics are driving the demand for multifunctional nanoagents. Upconversion nanoparticle (UCNP)-based systems activated by near-infrared (NIR) light deeply penetrating biotissue are a powerful tool for the simultaneous diagnosis and therapy of cancer. The intercalation into large polymer micelles of poly(maleic anhydride-alt-1-octadecene) [...] Read more.
Frontiers in theranostics are driving the demand for multifunctional nanoagents. Upconversion nanoparticle (UCNP)-based systems activated by near-infrared (NIR) light deeply penetrating biotissue are a powerful tool for the simultaneous diagnosis and therapy of cancer. The intercalation into large polymer micelles of poly(maleic anhydride-alt-1-octadecene) provided the creation of biocompatible UCNPs. The intrinsic properties of UCNPs (core@shell structure NaYF4:Yb3+/Tm3+@NaYF4) embedded in micelles delivered NIR-to-NIR visualization, photothermal therapy, and high drug capacity. Further surface modification of micelles with a thermosensitive polymer (poly-N-vinylcaprolactam) exhibiting a conformation transition provided gradual drug (doxorubicin) release. In addition, the decoration of UCNP micelles with Ag nanoparticles (Ag NPs) synthesized in situ by silver ion reduction enhanced the cytotoxicity of micelles at cell growth temperature. Cell viability assessment on Sk-Br-3, MDA-MB-231, and WI-26 cell lines confirmed this effect. The efficiency of the prepared UCNP complex was evaluated in vivo by Sk-Br-3 xenograft regression in mice for 25 days after peritumoral injection and photoactivation of the lesions with NIR light. The designed polymer micelles hold promise as a photoactivated theranostic agent with quattro-functionalities (NIR absorption, photothermal effect, Ag NP cytotoxicity, and Dox loading) that provides imaging along with chemo- and photothermal therapy enhanced with Ag NPs. Full article
(This article belongs to the Special Issue Potentialities and Challenges of Bio-Inspired Delivery Systems)
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15 pages, 3804 KiB  
Article
Proteolytic Resistance Determines Albumin Nanoparticle Drug Delivery Properties and Increases Cathepsin B, D, and G Expression
by Ekaterina P. Kolesova, Vera S. Egorova, Anastasiia O. Syrocheva, Anastasiia S. Frolova, Dmitry Kostyushev, Anastasiia Kostyusheva, Sergey Brezgin, Daria B. Trushina, Landysh Fatkhutdinova, Mikhail Zyuzin, Polina A. Demina, Evgeny V. Khaydukov, Andrey A. Zamyatnin, Jr. and Alessandro Parodi
Int. J. Mol. Sci. 2023, 24(12), 10245; https://doi.org/10.3390/ijms241210245 - 16 Jun 2023
Cited by 3 | Viewed by 1611
Abstract
Proteolytic activity is pivotal in maintaining cell homeostasis and function. In pathological conditions such as cancer, it covers a key role in tumor cell viability, spreading to distant organs, and response to the treatment. Endosomes represent one of the major sites of cellular [...] Read more.
Proteolytic activity is pivotal in maintaining cell homeostasis and function. In pathological conditions such as cancer, it covers a key role in tumor cell viability, spreading to distant organs, and response to the treatment. Endosomes represent one of the major sites of cellular proteolytic activity and very often represent the final destination of internalized nanoformulations. However, little information about nanoparticle impact on the biology of these organelles is available even though they represent the major location of drug release. In this work, we generated albumin nanoparticles with a different resistance to proteolysis by finely tuning the amount of cross-linker used to stabilize the carriers. After careful characterization of the particles and measurement of their degradation in proteolytic conditions, we determined a relationship between their sensitivity to proteases and their drug delivery properties. These phenomena were characterized by an overall increase in the expression of cathepsin proteases regardless of the different sensitivity of the particles to proteolytic degradation. Full article
(This article belongs to the Special Issue Potentialities and Challenges of Bio-Inspired Delivery Systems)
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13 pages, 5879 KiB  
Article
GNAQ-Regulated ZO-1 and ZO-2 Act as Tumor Suppressors by Modulating EMT Potential and Tumor-Repressive Microenvironment in Lung Cancer
by Hyung Seok Kim, Su In Lee, Yu Rim Choi, Jiyun Kim, Jung Woo Eun, Kyoung Seob Song and Jee-Yeong Jeong
Int. J. Mol. Sci. 2023, 24(10), 8801; https://doi.org/10.3390/ijms24108801 - 15 May 2023
Cited by 1 | Viewed by 1750
Abstract
Epithelial-to-mesenchymal transition (EMT) plays a critical role in the development and progression of lung cancer by promoting its invasiveness and metastasis. Using integrative analyses of the public lung cancer database, we found that the expression levels of the tight junction proteins, zonula occluden [...] Read more.
Epithelial-to-mesenchymal transition (EMT) plays a critical role in the development and progression of lung cancer by promoting its invasiveness and metastasis. Using integrative analyses of the public lung cancer database, we found that the expression levels of the tight junction proteins, zonula occluden (ZO)-1 and ZO-2, were lower in lung cancer tissues, including both lung adenocarcinoma and lung squamous cell carcinoma than in normal lung tissues analyzed using The Cancer Genome Atlas (TCGA). Although the ectopic expression or knockdown of ZO-1 and ZO-2 did not affect the growth of lung cancer cells, they significantly regulated cell migration and invasion. When M0 macrophages were co-cultured with ZO-1 or ZO-2 knockdown Calu-1 cells, M2-like polarization was efficiently induced. Conversely, co-culture of M0 THP-1 cells with A549 cells stably expressing ZO-1 or ZO-2 significantly reduced M2 differentiation. We also identified G protein subunit alpha q (GNAQ) as a potential ZO-1- and ZO-2-specific activator through analysis of correlated genes with the TCGA lung cancer database. Our results suggest that the GNAQ-ZO-1/2 axis may play a tumor-suppressive role in lung cancer development and progression and highlight ZO-1 and ZO-2 as key EMT- and tumor microenvironment-suppressive proteins. These findings provide new insights for the development of targeted therapies for lung cancer. Full article
(This article belongs to the Special Issue Potentialities and Challenges of Bio-Inspired Delivery Systems)
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20 pages, 13948 KiB  
Article
Hydrogel-Inducing Graphene-Oxide-Derived Core–Shell Fiber Composite for Antibacterial Wound Dressing
by Yuliya Kan, Julia V. Bondareva, Eugene S. Statnik, Elizaveta V. Koudan, Evgeniy V. Ippolitov, Mikhail S. Podporin, Polina A. Kovaleva, Roman R. Kapaev, Alexandra M. Gordeeva, Julijana Cvjetinovic, Dmitry A. Gorin, Stanislav A. Evlashin, Alexey I. Salimon, Fedor S. Senatov and Alexander M. Korsunsky
Int. J. Mol. Sci. 2023, 24(7), 6255; https://doi.org/10.3390/ijms24076255 - 26 Mar 2023
Cited by 2 | Viewed by 2266
Abstract
The study reveals the polymer–crosslinker interactions and functionality of hydrophilic nanofibers for antibacterial wound coatings. Coaxial electrospinning leverages a drug encapsulation protocol for a core–shell fiber composite with a core derived from polyvinyl alcohol and polyethylene glycol with amorphous silica (PVA-PEG-SiO2), [...] Read more.
The study reveals the polymer–crosslinker interactions and functionality of hydrophilic nanofibers for antibacterial wound coatings. Coaxial electrospinning leverages a drug encapsulation protocol for a core–shell fiber composite with a core derived from polyvinyl alcohol and polyethylene glycol with amorphous silica (PVA-PEG-SiO2), and a shell originating from polyvinyl alcohol and graphene oxide (PVA-GO). Crosslinking with GO and SiO2 initiates the hydrogel transition for the fiber composite upon contact with moisture, which aims to optimize the drug release. The effect of hydrogel-inducing additives on the drug kinetics is evaluated in the case of chlorhexidine digluconate (CHX) encapsulation in the core of core–shell fiber composite PVA-PEG-SiO2-1x-CHX@PVA-GO. The release rate is assessed with the zero, first-order, Higuchi, and Korsmeyer–Peppas kinetic models, where the inclusion of crosslinking silica provides a longer degradation and release rate. CHX medicated core–shell composite provides sustainable antibacterial activity against Staphylococcus aureus. Full article
(This article belongs to the Special Issue Potentialities and Challenges of Bio-Inspired Delivery Systems)
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