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Advanced Research on Macrophages in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 28 June 2024 | Viewed by 1372

Special Issue Editor


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Guest Editor
Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, Health Science Campus, El Palmar, E-30120 Murcia, Spain
Interests: innate immune system in host–pathogen interactions; inflammatory and immune-related human pathologies such as cirrhosis, cancer, and endometriosis; microbiome; development of novel therapeutic approaches to treat that type of diseases; testing vegetal bioactive compounds and newly synthesized drugs; human monocyte and macrophages in in vitro assays; mouse animal models

Special Issue Information

Dear Colleagues,

Macrophages are innate immune cells found in all tissues that show great plasticity and functional diversity; they are involved in development, homeostasis, tissue repair, and immunity. However, these functions can be subverted, resulting in a causal association of macrophages with disease states, making them important therapeutic targets in many human diseases.

In this Special Issue of IJMS, we will focus on the physiological functions of human macrophages developed under healthy conditions at the molecular level, the mechanisms involved in disease establishment and/or progression, and how some of these mechanisms could be exploited therapeutically. We will consider submissions of original research reports, reviews, and methodology articles.

Prof. Dr. María Martínez-Esparza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • macrophages
  • phenotype
  • plasticity
  • inflammation
  • molecular mechanisms
  • signaling pathways
  • human disease
  • immunopathology
  • immunotherapy
  • target identification
  • natural compounds
  • drugs

Published Papers (1 paper)

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Research

17 pages, 11954 KiB  
Article
Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation
by Silvia Kuntschar, Giulia Cardamone, Kevin Klann, Rebekka Bauer, Sofie Patrizia Meyer, Rebecca Raue, Peter Rappl, Christian Münch, Bernhard Brüne and Tobias Schmid
Int. J. Mol. Sci. 2023, 24(23), 16981; https://doi.org/10.3390/ijms242316981 - 30 Nov 2023
Viewed by 854
Abstract
Despite the importance of rapid adaptive responses in the course of inflammation and the notion that post-transcriptional regulation plays an important role herein, relevant translational alterations, especially during the resolution phase, remain largely elusive. In the present study, we analyzed translational changes in [...] Read more.
Despite the importance of rapid adaptive responses in the course of inflammation and the notion that post-transcriptional regulation plays an important role herein, relevant translational alterations, especially during the resolution phase, remain largely elusive. In the present study, we analyzed translational changes in inflammatory bone marrow-derived macrophages upon resolution-promoting efferocytosis. Total RNA-sequencing confirmed that apoptotic cell phagocytosis induced a pro-resolution signature in LPS/IFNγ-stimulated macrophages (Mϕ). While inflammation-dependent transcriptional changes were relatively small between efferocytic and non-efferocytic Mϕ; considerable differences were observed at the level of de novo synthesized proteins. Interestingly, translationally regulated targets in response to inflammatory stimuli were mostly downregulated, with only minimal impact of efferocytosis. Amongst these targets, pro-resolving matrix metallopeptidase 12 (Mmp12) was identified as a translationally repressed candidate during early inflammation that recovered during the resolution phase. Functionally, reduced MMP12 production enhanced matrix-dependent migration of Mϕ. Conclusively, translational control of MMP12 emerged as an efficient strategy to alter the migratory properties of Mϕ throughout the inflammatory response, enabling Mϕ migration within the early inflammatory phase while restricting migration during the resolution phase. Full article
(This article belongs to the Special Issue Advanced Research on Macrophages in Human Health and Disease)
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