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Host-Microbe Interactions in Ulcerative Colitis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 7615

Special Issue Editor

Deparment of Pathology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein zuid 10, 6525 GA Nijmegen, The Netherlands
Interests: host–microbe interactions; colorectal cancer; neoplasia; microbiome; Streptococcus gallolyticus; Bacteroides fragilis; oncotoxins; ulcerative colitis; epithelium; interventions

Special Issue Information

Dear Colleagues,

Ulcerative colitis is a chronic inflammatory condition of the gastrointestinal tract. Both genetic susceptibility and environmental factors are indicated as important factors in initiation and progression of the disease. Adverse reactions to commensal microbiota as well as pathogens that impair epithelial barrier function are important environmental factors that can impact gut homeostasis and severity of ulcerative colitis. Importantly, patients with ulcerative colitis have an increased risk for neoplasia development. Especially UC-patients with a long duration of disease (>10 years) have an increased risk of colitis-associated cancer (CAC). Although there is accumulating evidence that chronic inflammation promotes CAC, the cellular and microbial mechanisms contributing to this process are still unclear. Understanding the complex interaction between intestinal microbiota (commensal and pathogenic) and the host may provide crucial insights into the pathogenesis of CAC as well as interventions to prevent or treat the disease and reduce neoplasia development.

This Special Issue, “Host–Microbe Interactions in Ulcerative Colitis”, welcomes original research and review articles in the field, with a focus on but not limited to the molecular basis for neoplasia development in ulcerative colitis, regulation of host physiology and cellular function, in vitro and in vivo model systems for CAC as well as clinical research on the mucosal interaction between host and microbes contributing to neoplasia development in ulcerative colitis. In addition, studies investigating interventions or solutions to eliminate pathogens, strengthen epithelial barrier function, or tackle neoplasia development are encouraged.

Dr. Annemarie Boleij
Guest Editor

Manuscript Submission Information

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Keywords

  • ulcerative colitis
  • microbiome
  • pathogens
  • environment
  • genetics
  • neoplasia
  • host response
  • host–microbe crosstalk
  • epithelial barrier

Published Papers (2 papers)

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Review

34 pages, 1325 KiB  
Review
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
Int. J. Mol. Sci. 2021, 22(21), 11365; https://doi.org/10.3390/ijms222111365 - 21 Oct 2021
Cited by 27 | Viewed by 4747
Abstract
Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic [...] Read more.
Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies. Full article
(This article belongs to the Special Issue Host-Microbe Interactions in Ulcerative Colitis)
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17 pages, 1362 KiB  
Review
Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
Int. J. Mol. Sci. 2021, 22(19), 10851; https://doi.org/10.3390/ijms221910851 - 07 Oct 2021
Cited by 2 | Viewed by 2415
Abstract
Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previously, intestinal viruses were [...] Read more.
Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previously, intestinal viruses were thought to be either detrimental or neutral to the host. However, persisting viruses may have a role as resident commensals and confer protective immunity during inflammation. On the other hand, the dysregulation of gut mucosal immune responses to viruses can trigger excessive, pathogenic inflammation. The purpose of this review is to discuss virus-induced innate immune responses that are at play in ulcerative colitis. Full article
(This article belongs to the Special Issue Host-Microbe Interactions in Ulcerative Colitis)
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