Host-Microbe Interactions in Ulcerative Colitis
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 7615
Interests: host–microbe interactions; colorectal cancer; neoplasia; microbiome; Streptococcus gallolyticus; Bacteroides fragilis; oncotoxins; ulcerative colitis; epithelium; interventions
Ulcerative colitis is a chronic inflammatory condition of the gastrointestinal tract. Both genetic susceptibility and environmental factors are indicated as important factors in initiation and progression of the disease. Adverse reactions to commensal microbiota as well as pathogens that impair epithelial barrier function are important environmental factors that can impact gut homeostasis and severity of ulcerative colitis. Importantly, patients with ulcerative colitis have an increased risk for neoplasia development. Especially UC-patients with a long duration of disease (>10 years) have an increased risk of colitis-associated cancer (CAC). Although there is accumulating evidence that chronic inflammation promotes CAC, the cellular and microbial mechanisms contributing to this process are still unclear. Understanding the complex interaction between intestinal microbiota (commensal and pathogenic) and the host may provide crucial insights into the pathogenesis of CAC as well as interventions to prevent or treat the disease and reduce neoplasia development.
This Special Issue, “Host–Microbe Interactions in Ulcerative Colitis”, welcomes original research and review articles in the field, with a focus on but not limited to the molecular basis for neoplasia development in ulcerative colitis, regulation of host physiology and cellular function, in vitro and in vivo model systems for CAC as well as clinical research on the mucosal interaction between host and microbes contributing to neoplasia development in ulcerative colitis. In addition, studies investigating interventions or solutions to eliminate pathogens, strengthen epithelial barrier function, or tackle neoplasia development are encouraged.
Dr. Annemarie Boleij
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- ulcerative colitis
- host response
- host–microbe crosstalk
- epithelial barrier