Is Vesicular Therapy the Newcomer That Matters for the Medicine of Tomorrow? 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 155
Special Issue Editor
Interests: natural products; bioactive compounds; phenolics; plant derived compounds; medicinal plants; natural products chemistry; pre-formulation; hydrogel; wound healing; nanoparticle; cartilage; osteoarthritis; ectopic mineralization; liposomes; extracellular vesicles; biomaterials; nuclear receptors; oxidant stress; cellular signalisation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Vesicles are becoming significant drug delivery systems thanks to their capability to target specific tissues and cells to deliver bioactive molecules.
Liposomes are vesicles that stand out among different types of self-assembled vesicles, because of their amphiphilicity and their cytocompatibility. Moreover, man-made liposomes have a controllable lipid composition that favors the reuse of biosources from plant or animal sources.
Mesenchymal stem cells (MSCs) are used as therapeutic agents in cell-based therapy for inflammatory and degenerative diseases. A large number of experimental and clinical studies revealed that most MSC-mediated healing effects were attributed to the extracellular vesicles (EVs) they secrete. Recent studies showed that engineered EVs with surface modifications are appropriated tools for targeted drug delivery.
In addition to synthetic vesicles and EVs, “smarter” delivery systems can be engineered by creating hybrid EV-liposome carriers via membrane fusion. All these systems can be loaded in hydrogels to achieve sustained and controlled drug delivery.
Many challenges related to liposomes, EVs, and hybrid systems persist. For example, liposomes are still considered the most successful family of vesicular vectors within the field of medicine. However, after 60 years of research, their full potential has yet to be achieved, as only a trickle of liposomal drug formulations have reached the market. Going forward, engineering targeted controlled drug delivery systems is of major importance and can achieve a huge breakthrough in treating many diseases.
Therefore, this Special Issue of IJMS will focus on the advances of vesicular vectors in the field of medicine over the last 10 years, and how this can reinforce the development of new therapeutics. It will also emphasize critical problems and their resolutions: cytotoxic effects, leakage, stability problems, batch to batch reproducibility, effective sterilization methods, and scale-up impediments. Our aim is for this Special Issue to shine a light on multidisciplinary research that examines these developments.
Dr. Arnaud Bianchi
Guest Editor
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Keywords
- liposomes
- extracellular vesicles
- vectorization
- drug delivery
- targeting
- regenerative medicine
