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Clinical and Biological Perspectives on Erythrocyte Apoptosis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 462

Special Issue Editors


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Guest Editor
Faculty of Health Sciences, Ontario Tech University, 2000 Simcoe Street North, Oshawa, ON L1G 0C5, Canada
Interests: transfusion medicine; plasma and red blood cell transfusion; blood product characteristics; pathophysiology of red blood cells; erythropoiesis; anemia; cell signaling

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Guest Editor
Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, 72076 Tübingen, Germany
Interests: apoptosis; cells; phospholipids; kinase inhibitors

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Guest Editor
Department of Nephrol Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy
Interests: dialysis; uremia; cardiorenal syndrome; organ crosstalk; kidney; biomarkers; chronic kidney disease
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Special Issue Information

Dear Colleagues,

Erythrocytes are critical oxygen transporters and regulate a wide range of physiological functions to maintain homeostasis. In circulation, erythrocytes are exposed to various challenges and may become injured, which leads to their death and clearance. Increased erythrocyte death, also called eryptosis, has been shown to be associated with anemia related to various clinical conditions. In the last decade, a variety of intrinsic and extrinsic factors regulating erythrocyte survival have been comprehensively studied. Since these cells lack important organelles such as mitochondria and nucleus, specialized mechanisms regulate the apoptosis process. However, these processes and their clinical and biological significance in humans are not fully understood. This Special Issue aims to contribute to the growing body of knowledge on the clinical significance and mechanism of erythrocyte death. We are pleased to invite you to contribute original articles, short communications, and reviews on various aspects of erythrocyte apoptosis studied in human diseases, animal models and in vitro.

We look forward to receiving your contributions.

Dr. Syed Qadri
Dr. Rosi Bissinger
Dr. Grazia Maria Virzì
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • erythrocytes
  • apoptosis
  • eryptosis
  • anemia
  • systemic diseases

Published Papers (1 paper)

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Research

12 pages, 1293 KiB  
Article
Peritoneal Inflammation in PD-Related Peritonitis Induces Systemic Eryptosis: In Vitro and In Vivo Assessments
by Grazia Maria Virzì, Niccolò Morisi, Davide Marturano, Sabrina Milan Manani, Ilaria Tantillo, Claudio Ronco and Monica Zanella
Int. J. Mol. Sci. 2024, 25(8), 4284; https://doi.org/10.3390/ijms25084284 - 12 Apr 2024
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Abstract
Erythrocytes (RBCs) have a highly specialized and organized membrane structure and undergo programmed cell death, known as eryptosis. Our preliminary data show a significant increase in the eryptosis during peritoneal dialysis (PD)-associated peritonitis. The objectives of the present study were assessment of the [...] Read more.
Erythrocytes (RBCs) have a highly specialized and organized membrane structure and undergo programmed cell death, known as eryptosis. Our preliminary data show a significant increase in the eryptosis during peritoneal dialysis (PD)-associated peritonitis. The objectives of the present study were assessment of the incrementation of eryptosis in PD patients with peritonitis, evaluation of the relationship between systemic eryptosis in peritonitis and specific peritonitis biomarkers in PD effluent (PDE), and confirmation of the induction of eryptosis by peritonitis in a vitro setting. We enrolled 22 PD patients with peritonitis and 17 healthy subjects (control group, CTR). For the in vivo study, eryptosis was measured in freshly isolated RBCs. For the in vitro study, healthy RBCs were exposed to the plasma of 22 PD patients with peritonitis and the plasma of the CTR group for 2, 4, and 24 h. Eryptosis was evaluated by flow cytometric analyses in vivo and in vitro. PDE samples were collected for biomarkers analysis.The percentage of eryptotic RBCs was significantly higher in PD patients with peritonitis than in CTR (PD patients with peritonitis: 7.7; IQR 4.3–14.2, versus CTR: 0.8; IQR 0.7–1.3; p < 0.001). We confirmed these in vivo results by in vitro experiments: healthy RBCs incubated with plasma from PD patients with peritonitis demonstrated a significant increase in eryptosis compared to healthy RBCs exposed to plasma from the control group at all times. Furthermore, significant positive correlations were observed between eryptosis level and all analyzed peritoneal biomarkers of peritonitis. We investigated a potential connection between systemic eryptosis and peritoneal biomarkers of peritonitis. Up-regulation of inflammatory markers could explain the increased rate of systemic eryptosis during PD-related peritonitis. Full article
(This article belongs to the Special Issue Clinical and Biological Perspectives on Erythrocyte Apoptosis)
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