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Molecular Genetic Biology in Embryonic Development
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Molecular Genetic Biology in Embryonic Development

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 1410

Special Issue Editor

Dr. Adam Davis

E-Mail Website
Guest Editor
Department of Biology, University of North Georgia, Oakwood, GA 30566, USA
Interests: evolutionary and developmental biology; embryonic gene expression; vertebrate head development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Having a solid background on how genes pattern embryonic development is crucial for understanding the development of human disorders as well as the evolution of complex mechanisms that shape anatomical structures. Such mechanisms involve complex genetic regulatory networks; morphogenesis at the subcellular, cellular, and gross anatomical levels; and environmental interactions with the genome during embryonic development. This Special Issue of the International Journal of Molecular Sciences shall encompass articles on these mechanisms as well as others to help broaden our understanding of the genetic basis of embryonic development. Research manuscripts and comprehensive reviews adhering to the journal’s aims will be accepted.

Potential topics include, but are not limited to, the following:

  • Mechanisms of gene regulation during embryogenesis;
  • Differential gene expression at the levels of transcription, mRNA processing, translation, and protein modification;
  • Genetic regulation of early developmental processes, including fertilization, cleavage, and gastrulation;
  • Morphogenetic patterning mechanisms at subcellular, cellular, and gross anatomical levels
  • Genetic causes of medical disorders;
  • Genomic and environmental interactions on embryonic development;
  • Divergence in genetic regulatory mechanisms among evolutionary divergent lineages;
  • Evolution of divergent anatomical structures among evolutionary divergent lineages.

Dr. Adam Davis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • embryonic development
  • evolution and development
  • genetic regulatory networks
  • gene expression and regulation
  • cellular and subcellular morphogenesis
  • anatomical patterning
  • genomic– environmental interactions
  • axis development
  • medical disorders
  • molecular genetics

Published Papers (1 paper)

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Research

20 pages, 8883 KiB  
Article
The Effect of Temperature on the Embryo Development of Cephalopod Sepiella japonica Suggests Crosstalk between Autophagy and Apoptosis
by Yifan Liu, Long Chen, Fang Meng, Tao Zhang, Jun Luo, Shuang Chen, Huilai Shi, Bingjian Liu and Zhenming Lv
Int. J. Mol. Sci. 2023, 24(20), 15365; https://doi.org/10.3390/ijms242015365 - 19 Oct 2023
Viewed by 1024
Abstract
Temperature is a crucial environmental factor that affects embryonic development, particularly for marine organisms with long embryonic development periods. However, the sensitive period of embryonic development and the role of autophagy/apoptosis in temperature regulation in cephalopods remain unclear. In this study, we cultured [...] Read more.
Temperature is a crucial environmental factor that affects embryonic development, particularly for marine organisms with long embryonic development periods. However, the sensitive period of embryonic development and the role of autophagy/apoptosis in temperature regulation in cephalopods remain unclear. In this study, we cultured embryos of Sepiella japonica, a typical species in the local area of the East China Sea, at different incubation temperatures (18 °C, 23 °C, and 28 °C) to investigate various developmental aspects, including morphological and histological characteristics, mortality rates, the duration of embryonic development, and expression patterns of autophagy-related genes (LC3, BECN1, Inx4) and apoptosis marker genes (Cas3, p53) at 25 developmental stages. Our findings indicate that embryos in the high-temperature (28 °C) group had significantly higher mortality and embryonic malformation rates than those in the low-temperature (18 °C) group. Furthermore, high temperature (28 °C) shortened the duration of embryonic development by 7 days compared to the optimal temperature (23 °C), while low temperature (18 °C) caused a delay of 9 days. Therefore, embryos of S. japonica were more intolerant to high temperatures (28 °C), emphasizing the critical importance of maintaining an appropriate incubation temperature (approximately 23 °C). Additionally, our study observed, for the first time, that the Early blastula, Blastopore closure, and Optic vesicle to Caudal end stages were the most sensitive stages. During these periods, abnormalities in the expression of autophagy-related and apoptosis-related genes were associated with higher rates of mortality and malformations, highlighting the strong correlation and potential interaction between autophagy and apoptosis in embryonic development under varying temperature conditions. Full article
(This article belongs to the Special Issue Molecular Genetic Biology in Embryonic Development)
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