Sphingolipid Metabolism and Signaling in Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 August 2024 | Viewed by 3021
Special Issue Editor
Special Issue Information
Dear Colleagues,
We kindly invite you to contribute to this IJMS Special Issue entitled ‘Sphingolipid Metabolism and Signaling in Health and Diseases’ focused on the multifaceted aspects of sphingolipids' role in maintaining health and contributing to disease pathogenesis.
Sphingolipids, a diverse and ubiquitous group of lipids, are integral to several essential cellular functions and are implicated in various dysfunction and disease states. They are not only involved in intracellular trafficking and serve as structural components of cell membranes, providing stability and fluidity to the lipid bilayer, but also play various essential roles as secondary messengers in cell signaling pathways, regulating critical processes like cell growth, proliferation, and apoptosis. Additionally, sphingolipids are pivotal in maintaining cell integrity and barrier functions in the skin and gastrointestinal tract. Dysregulation of sphingolipid metabolism and altered signaling are implicated in various pathological conditions, including neurodegenerative disorders such as ALS, Alzheimer's, and Parkinson's, as well as cancer, diabetes, obesity, and cardiometabolic disorders. Moreover, chronic inflammation and immune system dysfunctions have been associated with sphingolipid imbalances, contributing to autoimmune diseases, chronic inflammatory states related to certain conditions, and aging.
In this Special Issue, we welcome original research articles and review articles that shed light on the underlying mechanisms, regulatory pathways, and interplay of sphingolipids in different physiological and pathological contexts, as well as submissions examining potential therapeutic interventions targeting sphingolipid signaling and metabolic pathways.
Dr. Gergana M. Deevska
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ceramide
- ceramide-1-phosphate
- sphingosine
- sphingosine-1-phosphate
- sphingomyelin
- glycosphingolipids
- metabolic syndrome
- obesity
- diabetes
- cancer
- neurodegeneration
- neuroinflammation
- autoimmunity
