Glycome and Nervous System 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2519
Special Issue Editors
Interests: glycobiology and disease implication; glycosyltransferases involved in N-linked glycans; reactive oxygen species; glutathione metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: glycoscience in brain and brain-related diseases; sialic acid biosynthesis; biomarker discovery; Alzheimer’s disease, glioma, platelet biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
More than 70% of proteins are modified with glycans: N-linked glycosylation to Asn residues and O-linked glycosylation to Ser or Thr residues. In the brain, several adhesion molecules and receptor proteins are modified with specific glycans and these glycans play important roles for high-order brain function. a2,8-Linked polysialic acid (polySia) is found in the N-linked glycans of neural cell adhesion molecules, N-CAMs, and is involved in cell–cell interaction during neural development and plasticity. A genome-wide association study shows that genetic variation of the polysialyltransferase gene is associated with mental disorders. HNK-1 epitope is predominantly expressed in the brains, modifies the N-linked glycans of several neural proteins, such as myelin-associated glycoprotein (MAG), L1, and glutamate receptor, and has a critical role for synaptic plasticity, spatial learning, and memory. Brain-specific b1,6-GlcNAc-branched O-mannosyl glycans decorate protein tyrosine phosphatase Z (PTPRZ), which is expressed in astrocytes and oligodendrocyte precursor cells. PTPRZ expression is markedly increased in brain tumors, and its shedding form in cerebrospinal fluid (CSF) is a promising diagnostic marker for glioma. In this Special Issue, we would explore how nerve-specific glycans carry out their roles in neural development, as well as interaction of nervous system and tumor environment.
Prof. Dr. Naoyuki Taniguchi
Prof. Dr. Shinobu Kitazume
Guest Editors
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Keywords
- polysialic acid
- HNK-1
- O-mannose glycan
- glycosylatransferases
- neural activity
- Alzheimer’s disease
- neural development
- psychiatric disease
- glioma
