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Gene Therapy in Neuropathy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 284

Special Issue Editor


E-Mail Website
Guest Editor
The Cyprus Institute of Neurology and Genetics, Ayios Dometios, Nicosia 2371, Cyprus
Interests: gene therapy for inherited neuropathies; electrophysiology; BNB disruption; oxaliplatin-induced neuropathy

Special Issue Information

Dear Colleagues,

Treatment of neurogenetic diseases has been supportive and symptomatic with various clinical signs including muscle weakness, slowing of nerve conduction velocities, shaking, developmental delay, and hypotonia. Recent discoveries of molecular mechanisms responsible for the development of these diseases have led to promising new therapies. Gene therapy approaches have been developed in recent decades; nevertheless, there are still some limitations to their extensive use in the clinic. Emerging therapies include the use of viral and nonviral approaches and different routes of administration for gene addition, silencing, replacement, modification, or repair, aiming for phenotypic improvement.

In this Special Issue of the International Journal of Molecular Sciences, we will provide an overview of the different gene therapy strategies developed for central and peripheral nervous system neuropathies. Limitations as well as further steps for clinical applications will be discussed in this Special Issue.

Dr. Alexia Kagiava
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gene therapy
  • adeno-associated viral vectors
  • lentiviral vectors
  • nanoparticles
  • antisense oligonucleotides
  • CRISPR Cas9
  • RNA
  • CNS
  • PNS

Published Papers

This special issue is now open for submission.
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