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Ion Channels in Eye Development, Health, and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 977

Special Issue Editors


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Guest Editor
Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Interests: synaptic transmission; calcium and vesicle dynamics; retina; ribbon synapse; neurodegeneration

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Guest Editor
Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Interests: inherited retinal dystrophies; age-related macular degeneration; glaucoma; gene therapy; inflammation
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Special Issue Information

Dear Colleagues,  

Ion channels are membrane-spanning multimeric proteins expressed by all living organisms and serve the purpose of transporting both organic and inorganic ions. The regulation of ions at a steady state level is a key phenomenon for proper cellular function. Recent advancements in imaging, physiology, crystallography, computational technology, molecular modeling, molecular biology tools, and systems genetics have facilitated an understanding of ion channels including the structure–function relationship of ion channels and the development of precision medicine.

The eye is an excellent model for understanding how the structure and function of ion channels correlate during development, health, and disease. This Special Issue aims to provide a comprehensive overview of the roles ion channels play from the perspective of the eye during development, health, disease, and potential therapeutic targets. This Special Issue welcomes original research papers, reviews, mini-reviews, perspectives, and opinion articles that will provide insights into the novel and existing approaches to:

  1. Explore specific roles of ion channels in development, health, and disease.
  2. Novel approaches to study the structure and function of ion channels.
  3. Current understanding of channelopathies and drug development.
  4. Studies in all animal species and models of retinal diseases are welcome, as are comparative studies across animal models.

Dr. Thirumalini Vaithianathan
Dr. T. J. Hollingsworth
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eye development
  • eye health and disease
  • ion channels
  • channelopathies
  • physiology
  • computational technology
  • molecular modeling
  • molecular biology tools
  • pharmacology
  • systems genetics

Published Papers (1 paper)

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Review

35 pages, 4883 KiB  
Review
The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease
by Johane M. Boff, Abhishek P. Shrestha, Saivikram Madireddy, Nilmini Viswaprakash, Luca Della Santina and Thirumalini Vaithianathan
Int. J. Mol. Sci. 2024, 25(4), 2226; https://doi.org/10.3390/ijms25042226 - 13 Feb 2024
Viewed by 713
Abstract
The intricate functionality of the vertebrate retina relies on the interplay between neurotransmitter activity and calcium (Ca2+) dynamics, offering important insights into developmental processes, physiological functioning, and disease progression. Neurotransmitters orchestrate cellular processes to shape the behavior of the retina under [...] Read more.
The intricate functionality of the vertebrate retina relies on the interplay between neurotransmitter activity and calcium (Ca2+) dynamics, offering important insights into developmental processes, physiological functioning, and disease progression. Neurotransmitters orchestrate cellular processes to shape the behavior of the retina under diverse circumstances. Despite research to elucidate the roles of individual neurotransmitters in the visual system, there remains a gap in our understanding of the holistic integration of their interplay with Ca2+ dynamics in the broader context of neuronal development, health, and disease. To address this gap, the present review explores the mechanisms used by the neurotransmitters glutamate, gamma-aminobutyric acid (GABA), glycine, dopamine, and acetylcholine (ACh) and their interplay with Ca2+ dynamics. This conceptual outline is intended to inform and guide future research, underpinning novel therapeutic avenues for retinal-associated disorders. Full article
(This article belongs to the Special Issue Ion Channels in Eye Development, Health, and Disease)
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