Gut Microbiota and Metabolic Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1489
Special Issue Editors
Interests: cell proliferation; autophagy; colon cancer; gastric cancer
Special Issues, Collections and Topics in MDPI journals
Interests: microbiome; nutrition; digestive diseases; metabolic syndrome; obesity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue “Gut Microbiota and Metabolic Diseases”.
Metabolic diseases, including obesity, diabetes mellitus, dyslipidemia, and fatty liver disease, represent a global epidemic and markedly heighten the risks for potentially life-threatening complications, including cardiovascular diseases, cancer, and stroke. With the recent advancements in metagenomics, it has now been shown that these metabolic disorders are closely associated with dysbiotic gut microbiota. Functionally, metabolic-disease-associated gut microbes could contribute to disease development via disrupting the intestinal barrier function, releasing microbe-associated molecular patterns (MAMPs) and toxins, modulating bile acid metabolism, and producing immunologically and metabolically bioactive metabolites (e.g., branched-chain amino acids, trimethylamine). The gut microbiota is also directly involved in energy harvesting and controls satiety and food intake through the gut–brain axis. In this respect, modification of the gut microbiota has been proposed as a novel strategy to prevent or treat metabolic disorders.
This Special Issue is focused on the mechanistic aspect by which dysbiotic gut microbiota interact with the host to contribute to the pathogenesis of metabolic disorders. Potential topics also include the use of fecal microbiota transplantation and prebiotics/probiotics/postbiotics as novel therapeutics for ameliorating metabolic functions.
Dr. William K.K. Wu
Dr. Sunny H. Wong
Guest Editors
Manuscript Submission Information
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Keywords
- metabolic syndromes
- obesity
- diabetes mellitus
- microbiome
- dyslipidemia
- adiposity
- insulin resistance
- fatty liver disease
