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Natural Products and Derivatives for the Management of Inflammatory Conditions
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Natural Products and Derivatives for the Management of Inflammatory Conditions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 1332

Special Issue Editors

Dr. Gabriele Carullo

E-Mail Website
Guest Editor
Department of Life Sciences, University of Siena, 53100 Siena, Italy
Interests: HDAC; vasorelaxant agents; antioxidant and anti-inflammatory nutraceuticals; leukemia; Pseudomonas aeruginosa; hybrid compounds; retinitis pigmentosa
Special Issues, Collections and Topics in MDPI journals
Dr. Isabella Romeo

E-Mail Website
Guest Editor
1. Dipartimento di Scienze della Salute, Università “Magna Græcia” di Catanzaro, 88100 Catanzaro, Italy 2. Net4Science Academic Spin-off, Università “Magna Græcia” di Catanzaro, 88100 Catanzaro, Italy
Interests: computational chemistry; medicinal chemistry; infectiouse disease; drug repurposing; virtual screening; molecular dynamics; antioxidant activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products represent a huge source of chemicals with a wide set of uses in drug discovery. Indeed, they emerged as a good starting point due to their interaction with different enzymes/receptors. In this context, not only polyphenols but also other classes of secondary metabolites showed themselves to be promising anti-inflammatory/anti-oxidant agents, fostering the development of new or repurposed pharmacological tools in both academia and industry. This was also spurred by the use of computational methods, which predict biochemical interactions that can be then confirmed in in vitro/ex vivo/in vivo studies.

In this Special Issue, we welcome review articles and original articles from chemical and biological point of views, ranging from drug discovery to biological/pharmacological studies and from virtual screening to fully integrated biochemical/pharmacological studies, in order to understand the full potential of natural products in drug research.

Dr. Gabriele Carullo
Dr. Isabella Romeo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant activity
  • anti-inflammatory agents
  • drug design
  • drug discovery
  • cancer
  • infectious disease
  • immunology
  • inflammation
  • molecular docking
  • virtual screening

Published Papers (1 paper)

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Research

24 pages, 17334 KiB  
Article
Acetyl-11-Keto-β-Boswellic Acid Accelerates the Repair of Spinal Cord Injury in Rats by Resisting Neuronal Pyroptosis with Nrf2
by Yao Wang, Zongliang Xiong, Qiyuan Zhang, Mengmeng Liu, Jingjing Zhang, Xinyue Qi, Xiaowen Jiang and Wenhui Yu
Int. J. Mol. Sci. 2024, 25(1), 358; https://doi.org/10.3390/ijms25010358 - 26 Dec 2023
Viewed by 868
Abstract
The primary aim of this study is to delve into the potential of Acetyl-11-keto-β-boswellic acid (AKBA) in ameliorating neuronal damage induced by acute spinal cord injury, as well as to unravel the intricate underlying mechanisms. A cohort of 40 Sprague-Dawley rats was meticulously [...] Read more.
The primary aim of this study is to delve into the potential of Acetyl-11-keto-β-boswellic acid (AKBA) in ameliorating neuronal damage induced by acute spinal cord injury, as well as to unravel the intricate underlying mechanisms. A cohort of 40 Sprague-Dawley rats was meticulously categorized into four groups. Following a seven-day oral administration of AKBA, damaged spinal cord samples were meticulously procured for Nissl staining and electron microscopy to assess neuronal demise. Employing ELISA, immunofluorescence, Western blot (WB), and quantitative polymerase chain reaction (qPCR), the modulatory effects of AKBA within the context of spinal cord injury were comprehensively evaluated. Furthermore, employing an ex vivo extraction of spinal cord neurons, an ATP + LPS-induced pyroptotic injury model was established. The model was subsequently subjected to Nrf2 inhibition, followed by a battery of assessments involving ELISA, DCFH-DA staining, flow cytometry, immunofluorescence, and WB to decipher the effects of AKBA on the spinal cord neuron pyroptosis model. By engaging the Nrf2-ROS-NLRP3 pathway, AKBA exerted a repressive influence on the expression of the pyroptotic initiator protein Caspase-1, thereby mitigating the release of GSDMD and alleviating pyroptosis. Additionally, AKBA demonstrated the ability to attenuate the release of IL-18 and IL-1β, curbing neuronal loss and expediting the restorative processes within the context of spinal cord injury. Our study elucidates that AKBA can reduce spinal cord neuronal apoptosis, providing a basis for the development of AKBA as a clinical treatment for spinal cord injury. Full article
(This article belongs to the Special Issue Natural Products and Derivatives for the Management of Inflammatory Conditions)
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