Molecular Advances and Insights into Brain Hypoxia
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 957
Special Issue Editor
Special Issue Information
Dear Colleagues,
Brain development and function rely on normal oxygen supply, and its disruption under hypoxia or ischemia is one of the pathological factors leading to neurological disabilities. Restricted oxygen supply to the brain significantly affects cellular functions, with immediate changes in membrane lipids and proteins, as well as long-term changes in gene expression. This can lead to impaired brain development and function in the case of prenatal or neonatal hypoxia and, in later life, can trigger various neurodegenerative disorders, including vascular dementia and Alzheimer’s disease. Acute and chronic brain hypoxia also severly affects the behaviour of individuals and their cognitive abilities, resulting in personality disorders.
In recent years, signficant efforts have been made to understand the molecular mechanisms of hypoxic brain injury, and in 2019, a group of hypoxia researchers (William Kaelin, Sir Peter Ratcliffe and Gregg Semenza) was awarded the Nobel Prize in Physiology or Medicine "for their discoveries of how cells sense and adapt to oxygen availability". The COVID-19 pandemic made it clear that hypoxia is one of the major factors accompanying this lethal disease. Neurological complications have been reported in a large number of COVID-19 patients, adding to the urgency of research relating hypoxia considering there are still limited numbers of new therapeutic targets and approaches to prevent the pathological outcomes of brain hypoxia and ischemia.
This Special Issue welcomes articles and review papers in all areas of hypoxia research, from basic biochemistry (studies in lipids, proteins and nucleic acids), molecular biology (gene expression and regulation), cellular biology (cell death, mitochondria and autophagy), brain morphology (including vascular status and functions of the blood–brain barrier), as well as behavioral and cognitive physiology. Special attention will be paid to the newly developed models and approaches to elucidate endogenous protective mechanisms of hypoxic pre- and postconditioning, and their possible neuroprotective applications.
Dr. Natalia N. Nalivaeva
Guest Editor
Manuscript Submission Information
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Keywords
- hypoxia
- ischemia
- HIF-1
- COVID-19
- hypoxic pre- and postconditioning
- gene expression
- cell death
- brain tolerance
- neurodegeneraion
- neuroprotection
