International Journal of Molecular Sciences

Journal Browser

► Journal Browser

New Insights of Main-Group and Transition Metal Compounds in Medicinal Chemistry

Share This Special Issue

Special Issue Editor

Dr. Diana V. Aleksanyan

E-Mail Website
Guest Editor

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences (INEOS RAS), ul. Vavilova 28, Moscow 119991, Russia
Interests: organophosphorus chemistry; coordination; organometallic chemistry; medicinal chemistry

Special Issue Information

Dear Colleagues,

Metal-based drugs are at the forefront of treating many diseases, including rheumatoid arthritis, leishmaniasis, peptic and duodenal ulcers, diabetes, and several neurodegenerative conditions, and they play a crucial role in cancer therapy. This Special Issue covers recent advances in the development of new antimicrobial, antifungal, antiviral, anti-inflammatory, and, especially, anticancer agents based on main group and transition metal compounds, which were possible due to the unique properties of metal ions and the multi-target ligand design. Different aspects of the creation of potential metal-containing therapeutics, in particular, chemotherapeutics, their structural characterization, as well as mechanisms of action, highlight the main achievements and challenges of modern medicinal inorganic chemistry.

This Special Issue welcomes original research papers and updated reviews related to the potential application of main group and transition metal compounds in the treatment of various diseases, including different types of cancer.

Dr. Diana V. Aleksanyan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

main-group metal compounds
transition metal compounds
anticancer agents
antimicrobial agents
antifungal agents
antiviral agents
anti-inflammatory agents

Published Papers (1 paper)

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

12 pages, 2335 KiB

Open AccessArticle

Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential

by Vladimir A. Kozlov, Diana V. Aleksanyan, Svetlana G. Churusova, Aleksandr A. Spiridonov, Ekaterina Yu. Rybalkina, Evgenii I. Gutsul, Svetlana A. Aksenova, Alexander A. Korlyukov, Alexander S. Peregudov and Zinaida S. Klemenkova

Int. J. Mol. Sci. 2023, 24(24), 17331; https://doi.org/10.3390/ijms242417331 - 10 Dec 2023

Cited by 1 | Viewed by 1240

Abstract

Driven by the growing threat of cancer, many research efforts are directed at developing new chemotherapeutic agents, where the central role is played by transition metal complexes. The proper ligand design serves as a key factor to unlock the anticancer potential of a particular metal center. Following a recent trend, we have prepared unsymmetrical pincer ligands that combine benzothiazole and thiocarbamate donor groups. These compounds are shown to readily undergo direct cyclopalladation, affording the target S,C,N-type Pd(II) pincer complexes both in solution and in the absence of a solvent. The solid-phase strategy provided the complexes in an efficient and ecologically friendly manner. The resulting palladacycles are fully characterized using nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy and, in one case, by single-crystal X-ray diffraction (XRD). The solvent-free reactions are additionally analyzed by powder XRD. The pincer complexes exhibit remarkable cytotoxicity against several solid and blood cancer cell lines, including human colorectal carcinoma (HCT116), breast cancer (MCF7), prostate adenocarcinoma (PC3), chronic myelogenous leukemia (K562), multiple plasmacytoma (AMO1), and acute lymphoblastic leukemia (H9), with the dimethylamino-substituted derivative being particularly effective. The latter also induced an appreciable level of apoptosis in both parental and doxorubicin-resistant cells K562 and K562/iS9, vindicating the high anticancer potential of this type of palladacycles. Full article

(This article belongs to the Special Issue New Insights of Main-Group and Transition Metal Compounds in Medicinal Chemistry)

► Show Figures

Journal Menu

Journal Browser

New Insights of Main-Group and Transition Metal Compounds in Medicinal Chemistry

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (1 paper)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI