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Molecular Research in Chemical Mixtures Toxicology
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Molecular Research in Chemical Mixtures Toxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 704

Special Issue Editor

Dr. Jung-taek Kwon

E-Mail Website
Guest Editor
National Institute of Environment Research, Incheon, Republic of Korea
Interests: toxicology of chemical mixtures; inhalation toxicology

Special Issue Information

Dear Colleagues,

In most household products, various chemical substances exist in the form of mixtures rather than as a single substance. Typically, a biocide is used as a preservative to prevent microbial contamination, along with a solvent or emulsifier that enhances the solubility of low water-soluble substances or enables their uniform distribution in a product. However, it is challenging to evaluate the toxicity of these mixtures with existing techniques, and there are limitations that have a high cost and long research period. Therefore, it is necessary to investigate the toxicity screening of mixtures containing biocides and solvents, which are the main contents of household chemical products. The International Journal of Molecular Sciences has opened this Special Issue focusing on the field of chemical mixture toxicology research and welcomes original research articles and review articles on mixture toxicity screening studies using fast and cost-effective techniques.

Dr. Jung-taek Kwon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mixtures toxicity
  • pulmonary toxicity
  • inhalation lung
  • screening
  • biocide
  • emulsifier
  • household products
  • spray

Published Papers (1 paper)

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Research

20 pages, 6433 KiB  
Article
Modeling PAH Mixture Interactions in a Human In Vitro Organotypic Respiratory Model
by Victoria C. Colvin, Lisa M. Bramer, Brianna N. Rivera, Jamie M. Pennington, Katrina M. Waters and Susan C. Tilton
Int. J. Mol. Sci. 2024, 25(8), 4326; https://doi.org/10.3390/ijms25084326 - 13 Apr 2024
Viewed by 400
Abstract
One of the most significant challenges in human health risk assessment is to evaluate hazards from exposure to environmental chemical mixtures. Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous contaminants typically found as mixtures in gaseous and particulate phases in ambient air [...] Read more.
One of the most significant challenges in human health risk assessment is to evaluate hazards from exposure to environmental chemical mixtures. Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous contaminants typically found as mixtures in gaseous and particulate phases in ambient air pollution associated with petrochemicals from Superfund sites and the burning of fossil fuels. However, little is understood about how PAHs in mixtures contribute to toxicity in lung cells. To investigate mixture interactions and component additivity from environmentally relevant PAHs, two synthetic mixtures were created from PAHs identified in passive air samplers at a legacy creosote site impacted by wildfires. The primary human bronchial epithelial cells differentiated at the air–liquid interface were treated with PAH mixtures at environmentally relevant proportions and evaluated for the differential expression of transcriptional biomarkers related to xenobiotic metabolism, oxidative stress response, barrier integrity, and DNA damage response. Component additivity was evaluated across all endpoints using two independent action (IA) models with and without the scaling of components by toxic equivalence factors. Both IA models exhibited trends that were unlike the observed mixture response and generally underestimated the toxicity across dose suggesting the potential for non-additive interactions of components. Overall, this study provides an example of the usefulness of mixture toxicity assessment with the currently available methods while demonstrating the need for more complex yet interpretable mixture response evaluation methods for environmental samples. Full article
(This article belongs to the Special Issue Molecular Research in Chemical Mixtures Toxicology)
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