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Special Issue "Galectins: Structure, Function and Therapeutic Inhibitors 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 60

Special Issue Editors

Institute of Biostructures and Bioimaging, CNR, 80134 Naples, Italy
Interests: protein–protein interactions; protein structure–function relationship; cell–macromolecules interactions; biophysical characterization; thermophilic microorganisms; protein disulfide oxidoreductase
Special Issues, Collections and Topics in MDPI journals
Institute of Biostructures and Bioimaging, CNR, 80134 Naples, Italy
Interests: molecular biology; cellular biology; biological chemistry; protein structure–function relationship; protein biophysical characterization
Special Issues, Collections and Topics in MDPI journals
1. Interuniversity Research Centre on Bioactive Peptides (CIRPeB), University of Naples “Federico II”, Via Mezzocannone 16, 80134 Napoli, Italy
2. Center for Life Sciences and Technologies (CESTEV), University of Naples “Federico II”, Via De Amicis, 80145 Naples, Italy
Interests: organic chemistry synthesis; carbohydrate chemistry; protein–carbohydrate interaction; protein–peptide interaction; medicinal chemistry; cell biology; cytofluorimetry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Galectins, β-galactoside-binding proteins, have been shown to participate in diverse and relevant biological functions via their interactions with β-galactoside-containing structures on the cell surface. More importantly, human galectins act as regulatory factors in many types of pathologies by either inhibiting or promoting them. Therefore, to identify selective ligands for human galectins provides not only a useful tool for dissecting how each galectin member interacts with specific glycan structures, but also a possible solution for the development of clinical therapeutics. In this regard, this Special Issue focuses on the characterization of different members belonging to this family, studying not only the interaction with newly selected inhibitors by different biophysical techniques, but also characterizing their potential biological activity. All researchers working in the field are cordially invited to contribute original research articles or reviews to this Special Issue.

Due to the success of the 1st edition, we would like to add more results and new insights from recent research projects.


Dr. EmiliaMaria Pedone
Dr. Sonia Di Gaetano
Dr. Domenica Capasso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • galectin
  • inhibitor
  • CRD
  • glyconiugates
  • glycomimetics
  • peptidic ligands
  • selectivity, binding constants
  • protein–ligand interaction
  • galectin–ligand structure

Related Special Issue

Published Papers

This special issue is now open for submission.
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