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The Evolution, Genetics and Pathogenesis of Viruses

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1643

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Guest Editor
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk, 61-704 Poznan, Poland
Interests: RNA/DNA structure; G-quadruplex; influenza virus; structural biology; RNA/DNA thermodynamic
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Special Issue Information

Dear Colleagues, 

Viruses are an important research subject around the world because of their serious threat to humanity. The current COVID-19 pandemic is unprecedented with regard to the rate of spread and mortality rate. Moreover, a lack of knowledge of the mode of transmission and spread of the virus makes it difficult to fight the infection. Overall, the pandemic potential of viruses is a result of the high variability of their genome and is correlated with their pathogenicity, replication, and growth kinetics. It is known that the nature of the viral genome (RNA or DNA) plays an important role in its genetics. Therefore, a detailed analysis of the viral genetic material, including its structure, function–structure relationships, and virus–host interactions allow us to provide new insights into viral infections. In the future, it also might be useful for the determination of potential antiviral targets within viral genomes, as well as for designing and developing new therapeutics.

Dr. Marta Szabat
Guest Editor

Manuscript Submission Information

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Keywords

  • viruses
  • genome structure
  • viral RNA/DNA
  • replication viral cycle
  • recombination
  • viral infection
  • antiviral agents

Published Papers (1 paper)

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Research

13 pages, 73363 KiB  
Article
Phylogenetic Analysis and Serological Investigation of Porcine Circovirus Indicates Frequent Infection with Various Subtypes
by Qianling Peng, Jiqiang Shi, Yifei Lang, Yulan Zhu, Xiaobo Huang, Sanjie Cao, Qigui Yan and Shan Zhao
Int. J. Mol. Sci. 2023, 24(21), 15850; https://doi.org/10.3390/ijms242115850 - 01 Nov 2023
Viewed by 1114
Abstract
Porcine circoviruses (PCVs) are notorious for triggering severe diseases in pigs and causing serious economic losses to the swine industry. In the present study, we undertook a comprehensive approach for the investigation of PCV prevalence, including the phylogenetic analysis of obtained PCV sequences, [...] Read more.
Porcine circoviruses (PCVs) are notorious for triggering severe diseases in pigs and causing serious economic losses to the swine industry. In the present study, we undertook a comprehensive approach for the investigation of PCV prevalence, including the phylogenetic analysis of obtained PCV sequences, the determination of major circulating genotypes and serological screening based on different recombinant Cap proteins with specific immunoreactivity. Epidemiological surveillance data indicate that PCV2d and PCV3a are widely distributed in Southwest China, while PCV4 has only sporadic circulation. Meanwhile, serological investigations showed high PCV2 antibody positivity in collected serum samples (>50%), followed by PCV4 (nearly 50%) and PCV3 (30–35%). The analysis supports different circulation patterns of PCV2, PCV3 and PCV4 and illustrates the PCV2/PCV3 genetic evolution characteristics on a nationwide basis. Taken together, our findings add up to the current understanding of PCV epidemiology and provide new tools and insight for PCV antiviral intervention. Full article
(This article belongs to the Special Issue The Evolution, Genetics and Pathogenesis of Viruses)
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