Peroxisome and Lysosome in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 August 2024 | Viewed by 41
Special Issue Editor
Interests: oxysterols; very-long-chain fatty acids; lipid metabolism; diet, peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is dedicated to peroxisomes and lysosomes, identified by C. De Duve.
Peroxisomes are genome-free intracellular organelles performing essential metabolic functions: beta-oxidation of very long-chain fatty acids, catabolism of prostaglandins and polyamines, first reactions in the biogenesis of plasmalogens (e.g., PAF-acetate) and bile salts, degradation of H202 , etc. There are many peroxisomal diseases, e.g., genetic disorders, which affect peroxisome formation or impair a single enzymatic or transport function. With the exception of X-linked adrenoleukodystrophy, these diseases are transmitted in an autosomal recessive manner. Their presentation is heterogeneous, with neonatal, infantile, and adult forms. In recent years, peroxisomes have also been implicated in immunity.
Lysosomes, small spherical structures delimited by a lipid membrane and located in the cytoplasm of eukaryotic cells, are cellular organelles whose hydrolytic enzymes play an essential role in the degradation of intracellular molecules and organelles (autophagy) and in the destruction of molecules ingested by the cell (heterophagy). They are the site of two pathologies, one non-specific, which occurs following any hepatic damage, the other specific, hereditary, which depends on the structure of the lysosome itself, in particular its enzymatic equipment. The term “lysosomal diseases” covers around fifty disabling conditions in children and adults, all of which have one thing in common: a genetic defect that causes the lysosome to malfunction. The lysosome no longer performs its function of recycling and eliminating waste. Metabolites gradually accumulate in the cells and, consequently, in the tissues of the body of the sick child or adult, disrupting their functioning. This accumulation leads to the appearance of lesions in various organs, including the bones, heart, lungs, liver, spleen, and brain, causing particularly serious and irreversible disorders.
These pathologies, whether peroxisomal or lysosomal, have few treatments available. We therefore need to know more about these organelles and their functions in order to better understand the pathophysiology of their associated diseases and thus identify possible new treatments.
Dr. Anne Vejux
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- peroxisomes
- lysosomes
- autophagy
- lysosomal diseases
- peroxidase
- oxidative stress
- acid hydrolase
- lysosomal storage disease(LSD)
- gaucher disease
