Autophagy and Oxidative Stress
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2463
Special Issue Editors
Interests: autophagy; mitochondria; post-translational modifications; oxidative stress; cancer therapy
Special Issue Information
Dear Colleagues,
Autophagy is an evolutionarily conserved catabolic process used to recycle cytoplasmic material. This process is enabled through the formation of a double membrane vesicle called an autophagosome, which transports cellular material to lysosomes for degradation, and allows cells to maintain cellular homeostasis under basal conditions and ensure survival after exposure to stress factors. Recently, many selective autophagy types, including mitophagy, ER-phagy, and ribophagy, have been investigated and found to play important roles in the physiological functions. Oxidative stress is closely associated with autophagy that resulting from various exogenous and endogenous stimuli, such as DNA damage, and chemotherapeutic drugs. It is interesting to investigate how cells fine-tune the balance between homeostasis and stress and navigate the decision between survival and cell death. Therefore, efforts to modify autophagy and oxidative stress pathways to improve disease therapy are necessary, ; however, much remains to be understood about their regulators, their modifications, and some relavant relevant disease states (such as cancers). Targeting essential components of the autophagy machinery may be the leading therapeutical strategy for clinical treatment. Many small molecules, like hydroxychloroquine and rapamycin et al., and natural products (quercetin and liensinine, et al.) were proved to exhibit a significant therapeutic effect on diseases. It is interesting to understand the role of autophagy and oxidative stress regulators in diseases and mining effective drugs for clinical treatment. The topic of this special issue is cell biology, clinical advances in autophagy and oxidative stress, and new treatment strategies, including targeted therapies or immunotherapies. Studies using animal or cell culture models to investigate molecular mechanisms of autophagy or oxidative stress, new autophagy or oxdative stress inducer/inhibitor, as well as stratagies for the treatment of diseases related to autophagy and oxidative stress will be published. Special attention will be given to studies on molecular mechanisms, therapeutic targets and autophagy or oxdative stress inducer/inhibitor.
For this Special Issue, we invite authors to submit novel work or reviews establishing the importance of autophagy or oxidative stress in the cell biology or pathology of human diseases, including cancer. This Special Issue aims at shedding new light on how autophagy and oxidative stress lead to an increase in disease pathology. Moreover, it aims at highlighting the cross-talk between autophagy and oxidative stress responses in the context of human diseases and relevant biomarker discovery.
Dr. Yang Wang
Prof. Dr. Qing-Yu He
Guest Editors
Manuscript Submission Information
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Keywords
- autophagy
- oxidative stress
- human diseases
- cancer
- drug
- biomarker
- therapy
- multi-omics
