Different Functions and Roles of microRNAs in Human Disease—Development, Progress and Challenges 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 552
Special Issue Editor
Interests: HIV/AIDS; SARS coronaviruses; influenza viruses; neurodegenerative diseases; genomics and epigenomics; ageing; highthroughput molecular technologies; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The microRNAs (miRNAs) are a new class of small non-coding RNAs which function as negative regulators of gene expression. Currently there are approximately 1700 miRNAs in the human genome but they are able to exert control over thousands of genes. Given this profound regulator capacity, they have regulatory roles in major physiologic processes and pathways, encompassing cell development, cell differentiation, proliferation, apoptosis, and immune responses. The biogenesis of these miRNAs is a series of highly coordinated enzymatic steps and in certain pathological states, the biogenesis machinery is disrupted leading to the deregulation of the miRNA milieu. The dysregulation of miRNA expression patterns has been directly associated with the pathogenesis of many human diseases ranging from viral infections, neurodegenerative diseases to cancers. The recent development of high-throughput technologies and reagents to identify, mimic, and suppress miRNAs has opened new avenues for the diagnosis, prognosis and therapeutics for treating a variety of human diseases. In this Special Issue, we highlight the role of these miRNAs in cancer, viral infections neurodegenerative diseases, metabolic diseases, and other related human diseases. Each review will provide an excellent snapshot of latest findings on these topical issues.
Potential topics include but are not limited to the following:
- miRNAs in human diseases (Encompassing human diseases along with defining its heterogeneity in cancer, neurodegenerative diseases, diabetes/metabolic diseases, and viral infections)
- Alternative processing of microRNAs in diseases
- MicroRNA biogenesis in mammalian cells
- Role of MicroRNA in the development of immune system (miRNAs involved in the development and regulation of the immune system during infections and other human diseases where immune system plays a vital role in dysregulation of the disease)
- miRNA and drug response (How miRNA can predict drug response, its durability and also how this can be integrated clinically for various human diseases outlined for this Special Issue. Update on miRNA that are in medical use as therapeutics)
- MicroRNAs (miRNAs) as a new class of biomarkers (miRNAs as novel biomarkers of diabetes: Challenges with the classical biomarkers to predict diabetes; cancer, metabolic diseases, and neurodegenerative diseases)
- Circulating miRNA as diagnostics, and their role in cause and effect of a disease (miRNA from body fluids such as plasma, serum, saliva, tears, vesicular bodies, semen and CSF as diagnostics. Update on biomarkers that are in medical use)
- Technical and biological advances and challenges in miRNA detection, analysis, and medical integration.
Dr. Nitin Saksena
Guest Editor
Manuscript Submission Information
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Keywords
- micro-RNA
- infectious diseases
- immune system
- cancer
- neurodegeneration
- metabolic diseases
- biomarkers
- miRNA diagnostics
