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Metabolism and Diseases Related to Thyroid Function

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1379

Special Issue Editors


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Guest Editor
Department of Internal Medicine, Division of Endocrinology and Metabolism, Gunma University Graduate School of Medicine, 3-39-15, Showa, Maebashi 371-8511, Japan
Interests: thyroid; pituitary; TSH; thyroid hormone; thyroid hormone receptor; cancer; diabetes mellitus

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Guest Editor
Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
Interests: thyroid; endocrinology; diabetes medicine

Special Issue Information

Dear Colleagues,

Thyroid hormones play a crucial role in the metabolism of glucose, lipids, and proteins—intricate biochemical processes within our bodies. These hormones, primarily thyroxine (T4) and triiodothyronine (T3), are secreted by the thyroid gland and are stimulated by pituitary thyroid-stimulating hormone (TSH). The feedback loop system associated with thyroid hormone production and release significantly impacts the rate at which our cells utilize energy. Their influence spans across nearly every tissue and organ, including the heart, brain, muscles, and digestive system.

This Special Issue aims to bring together cutting-edge research and insights into the mechanisms underlying thyroid hormone action, metabolism regulation, and therapeutic interventions. Submissions from researchers and clinicians in the field of endocrinology, biochemistry, and related disciplines are encouraged.

We welcome the submission of original research articles that explore the intricate relationship between thyroid hormone function and metabolism, as well as their implications in diseases such as hypothyroidism, hyperthyroidism, and thyroid cancer. Pure clinical or model studies will not be suitable for this journal. However, clinical or pure model submissions with biomolecular experiments are welcomed.

Dr. Eijiro Yamada
Dr. Shunichi Matsumoto
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • thyroid function
  • metabolism
  • diabetes mellitus
  • dyslipidemia
  • obesity
  • cancer

Published Papers (1 paper)

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Research

11 pages, 2418 KiB  
Article
Role of Thyroid Hormone in Dynamic Variation of gdf6a Gene during Metamorphosis of Paralichthys olivaceus
by Yaxin Shi, Junqiang Qiu, Xike Li, Yue Lin, Wenjuan Li, Jilun Hou and Yuanshuai Fu
Int. J. Mol. Sci. 2024, 25(1), 23; https://doi.org/10.3390/ijms25010023 - 19 Dec 2023
Viewed by 681
Abstract
The Japanese flounder (Paralichthys olivaceus) is a marine fish that undergoes a dramatic postembryonic metamorphosis, with the right eye shifting to the left and its lifestyle transitioning from planktonic to benthic. As the light environment of the habitat changes from bright [...] Read more.
The Japanese flounder (Paralichthys olivaceus) is a marine fish that undergoes a dramatic postembryonic metamorphosis, with the right eye shifting to the left and its lifestyle transitioning from planktonic to benthic. As the light environment of the habitat changes from bright to dim, its photoreceptor system also undergoes adaptive change. Growth differentiation factor 6a (Gdf6a) is a member of the BMP family, which plays a key role in regulating the dorsal–ventral pattern of the retina and photoreceptor fate, and the differentiation of different photoreceptors is also modulated by a thyroid hormone (TH) binding its receptor (TR). However, the relationship between gdf6a and TH and its role in the regulation of photoreceptors during flounder metamorphosis is still poorly understood. In this study, bioinformatics analysis showed that Gdf6a had a conserved TGFB structural domain and clusters with fishes. The expression analysis showed that the expression of gdf6a was highest in the eye tissue of adult flounder and tended to increase and then decrease during metamorphosis, reaching its highest levels at the peak of metamorphosis. Moreover, the expression of gdf6a increased in the early stages of metamorphosis after exogenous TH treatment, while it was inhibited after exogenous thiourea (a TH inhibitor, TU) treatment. To further investigate the targeting role of TH and gdf6a in the metamorphosis of flounder, the results of the Dual-Luciferase revealed that triiodothyronine (T3) may regulate the expression of gdf6a through TRβ. In conclusion, we speculate that TH influences the development of cone photoreceptors during the metamorphosis of the flounder by regulating the expression of gdf6a. Full article
(This article belongs to the Special Issue Metabolism and Diseases Related to Thyroid Function)
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