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Innovative Scaffolds in Regenerative Medicine and Other Biomedical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2887

Special Issue Editor


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Guest Editor
Department of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
Interests: bone; biomaterials; cells; tissue engineering; cartilage; angiogenesis; 3D printing; extracellular matrix; periodontal
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Special Issue Information

Dear Colleagues,

I invite you and your research group to submit a research article to a Special Issue of the International Journal of Molecular Science titled "Innovative Scaffolds in Regenerative Medicine and Other Biomedical Applications 2.0". In regenerative medicine, scaffolds are designed to mimic the extracellular matrix of the tissue, providing a suitable microenvironment for cell adhesion, proliferation and differentiation. These scaffolds can be fabricated from natural or synthetic materials, or a combination of both, depending on the specific requirements of the application. Advanced scaffold fabrication techniques, including 3D printing, electrospinning and self-assembly, enable the creation of complex architectures, with precise control over the scaffold's physical and mechanical properties. These techniques allow for the incorporation of growth factors, genes and other bioactive agents into the scaffold, enhancing tissue regeneration and promoting specific cellular responses. Furthermore, scaffold-based approaches have been explored for the development of implantable devices, tissue adhesives and biosensors.

This Special Issue is focused on the use of scaffolds in tissue regeneration. Research papers on the applications of scaffolds to other biomedical applications are also welcome. The integration of advanced technologies such as biofabrication, bioink development and tissue engineering principles, is driving the development of more sophisticated scaffolds for regenerative medicine and biomedical applications. Due to the nature of this journal and its audience, publications should feature at least some discussion of the results at a molecular level.

Dr. Marta S. Carvalho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • electrospun fibers
  • 3D printing
  • polymers
  • tissue engineering
  • bone regeneration
  • angiogenesis
  • wound healing
  • drug delivery
  • stimuli-responsive

Published Papers (2 papers)

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Review

48 pages, 7826 KiB  
Review
Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications
by Agnieszka Grzelak, Aleksandra Hnydka, Julia Higuchi, Agnieszka Michalak, Marta Tarczynska, Krzysztof Gaweda and Katarzyna Klimek
Int. J. Mol. Sci. 2024, 25(3), 1525; https://doi.org/10.3390/ijms25031525 - 26 Jan 2024
Viewed by 1278
Abstract
Platelet concentrates such as platelet-rich plasma, platelet-rich fibrin or concentrated growth factors are cost-effective autologous preparations containing various growth factors, including platelet-derived growth factor, transforming growth factor β, insulin-like growth factor 1 and vascular endothelial growth factor. For this reason, they are often [...] Read more.
Platelet concentrates such as platelet-rich plasma, platelet-rich fibrin or concentrated growth factors are cost-effective autologous preparations containing various growth factors, including platelet-derived growth factor, transforming growth factor β, insulin-like growth factor 1 and vascular endothelial growth factor. For this reason, they are often used in regenerative medicine to treat wounds, nerve damage as well as cartilage and bone defects. Unfortunately, after administration, these preparations release growth factors very quickly, which lose their activity rapidly. As a consequence, this results in the need to repeat the therapy, which is associated with additional pain and discomfort for the patient. Recent research shows that combining platelet concentrates with biomaterials overcomes this problem because growth factors are released in a more sustainable manner. Moreover, this concept fits into the latest trends in tissue engineering, which include biomaterials, bioactive factors and cells. Therefore, this review presents the latest literature reports on the properties of biomaterials enriched with platelet concentrates for applications in skin, nerve, cartilage and bone tissue engineering. Full article
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22 pages, 3515 KiB  
Review
A Comprehensive Look at In Vitro Angiogenesis Image Analysis Software
by Mariana Pereira, Jéssica Pinto, Belén Arteaga, Ana Guerra, Renato Natal Jorge, Fernando Jorge Monteiro and Christiane Laranjo Salgado
Int. J. Mol. Sci. 2023, 24(24), 17625; https://doi.org/10.3390/ijms242417625 - 18 Dec 2023
Cited by 2 | Viewed by 1268
Abstract
One of the complex challenges faced presently by tissue engineering (TE) is the development of vascularized constructs that accurately mimic the extracellular matrix (ECM) of native tissue in which they are inserted to promote vessel growth and, consequently, wound healing and tissue regeneration. [...] Read more.
One of the complex challenges faced presently by tissue engineering (TE) is the development of vascularized constructs that accurately mimic the extracellular matrix (ECM) of native tissue in which they are inserted to promote vessel growth and, consequently, wound healing and tissue regeneration. TE technique is characterized by several stages, starting from the choice of cell culture and the more appropriate scaffold material that can adequately support and supply them with the necessary biological cues for microvessel development. The next step is to analyze the attained microvasculature, which is reliant on the available labeling and microscopy techniques to visualize the network, as well as metrics employed to characterize it. These are usually attained with the use of software, which has been cited in several works, although no clear standard procedure has been observed to promote the reproduction of the cell response analysis. The present review analyzes not only the various steps previously described in terms of the current standards for evaluation, but also surveys some of the available metrics and software used to quantify networks, along with the detection of analysis limitations and future improvements that could lead to considerable progress for angiogenesis evaluation and application in TE research. Full article
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