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Special Issue "Alpha-Synuclein Amyloid Fibril Formation: New Molecular Perspectives"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 189

Special Issue Editor

Sector of Amyloid Research, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, 10257 Vilnius, Lithuania
Interests: amyloid fibril; protein aggregation; secondary structure; β-sheet; amide II; amyloids; prion proteins; fibril structure; s100a9; synuclein; amyloid proteins; fibrils; FTIR; AFM

Special Issue Information

Dear Colleagues, 

Alpha-synuclein is linked with multiple neurodegenerative disorders, including Parkinson‘s disease, dementia with Lewy bodies, and multiple-system atrophy. It is also known to be associated with amyloid plaques found in patients suffering from Alzheimer‘s disease. Investigations into the subject of alpha-synuclein amyloid aggregation have demonstrated the protein’s ability to form multiple structurally diverse fibril strains and suggested their link with distinct synucleinopathies. These alpha-synuclein strains carry diverse levels of seeding, propagation, and neurotoxicity potential. Therefore, an immense amount of effort has been dedicated towards deciphering the underlying factors which determine this prion-like structural variability, including genetic mutations, environmental conditions, co-interactions with other proteins, and the recent discovery of liquid–liquid phase separation of alpha-synuclein. Despite tremendous progress in this field, there are still various unknown or unexplored factors regarding the transition from native state alpha-synuclein to its pathogenic variants. The purpose of this Special Issue is to collect scientific articles and reviews that can provide new molecular perspectives in the field of alpha-synuclein amyloid fibril formation.

Dr. Mantas Žiaunys
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • alpha-synuclein
  • amyloid
  • protein aggregation
  • synucleinopathies
  • protein fibrils
  • protein misfolding
  • prion-like
  • protein-protein interactions

Published Papers

This special issue is now open for submission.
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