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The Roles of Kinds of Hormones in the Cardiovascular System

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4827

Special Issue Editor


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Guest Editor
Department of Translational and Precision Medicine, Unit of Secondary Arterial Hypertension, “Sapienza” University of Rome, Viale del Policlinico 155, 00165 Rome, Italy
Interests: hypertension; endothelial dysfunction; ischemic heart disease; arrhythmia; target organ damage; cardiovascular risk factors
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Special Issue Information

Dear Colleagues, 

Hormones are highly effective biologically active substances secreted by endocrine glands or endocrine cells, which act as messengers in the body to regulate its physiological processes. Hormones affect everything that happens in human body, including the heart. The cardiovascular system is governed by types of hormonal regulation, such as growth hormone, thyroid hormone, sex hormones, aldosterone, etc. Numerous studies have confirmed that hormones and cardiovascular diseases are closely related: growth hormone can promote myocardial tissue growth and improve cardiac function; the target organ of thyroxine is the heart; sex hormones play an irreplacable role in atherosclerosis (AS); and excess aldosterone directly causes important changes in the heart and vascular system. Additionally, whether hormone replacement therapy protects the cardiovascular system or increases the risk of cardiovascular disease is worthy of continued exploration.

The purpose of this Special Issue is to highlight the direct roles of different types of hormones in the cardiovascular system.

Dr. Luigi Petramala
Guest Editor

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Keywords

  • hormone
  • growth hormone
  • thyroid hormone
  • sex hormones
  • aldosterone
  • heart
  • cardiovascular
  • cardiac cells
  • vascular system
  • metabolic alterations
  • oxidative stress
  • thrombosis

Published Papers (1 paper)

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Review

16 pages, 996 KiB  
Review
The Effect of Aldosterone on Cardiorenal and Metabolic Systems
by Hiromasa Otsuka, Masanori Abe and Hiroki Kobayashi
Int. J. Mol. Sci. 2023, 24(6), 5370; https://doi.org/10.3390/ijms24065370 - 11 Mar 2023
Cited by 4 | Viewed by 4443
Abstract
Aldosterone, a vital hormone of the human body, has various pathophysiological roles. The excess of aldosterone, also known as primary aldosteronism, is the most common secondary cause of hypertension. Primary aldosteronism is associated with an increased risk of cardiovascular disease and kidney dysfunction [...] Read more.
Aldosterone, a vital hormone of the human body, has various pathophysiological roles. The excess of aldosterone, also known as primary aldosteronism, is the most common secondary cause of hypertension. Primary aldosteronism is associated with an increased risk of cardiovascular disease and kidney dysfunction compared to essential hypertension. Excess aldosterone can lead to harmful metabolic and other pathophysiological alterations, as well as cause inflammatory, oxidative, and fibrotic effects in the heart, kidney, and blood vessels. These alterations can result in coronary artery disease, including ischemia and myocardial infarction, left ventricular hypertrophy, heart failure, arterial fibrillation, intracarotid intima thickening, cerebrovascular disease, and chronic kidney disease. Thus, aldosterone affects several tissues, especially in the cardiovascular system, and the metabolic and pathophysiological alterations are related to severe diseases. Therefore, understanding the effects of aldosterone on the body is important for health maintenance in hypertensive patients. In this review, we focus on currently available evidence regarding the role of aldosterone in alterations of the cardiovascular and renal systems. We also describe the risk of cardiovascular events and renal dysfunction in hyperaldosteronism. Full article
(This article belongs to the Special Issue The Roles of Kinds of Hormones in the Cardiovascular System)
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