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Cellular and Molecular Studies of Dopamine and Its Receptors

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 530

Special Issue Editor


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Guest Editor
Department of Neuroscience, University of Florida, Gainesville, FL 32611, USA
Interests: neuroscience; dopamine; dopamine receptors; neuropharmacology

Special Issue Information

Dear Colleagues,

Dopamine is a neurotransmitter that plays a pivotal role in the brain’s communication system, serving as a chemical messenger that transmits signals between nerve cells and immune cells involved in mood regulation, motivation, reward processing, motor control and peripheral immunity. Dopamine receptors are located on the surface membrane serving as docking sites for dopamine molecules, allowing them to exert their effects on the target cells. There are several types of dopamine receptors, classified into D1-like (D1 and D5) and D2-like (D2, D3, and D4) subtypes, each with distinct functions and signaling pathways. The interaction between dopamine and its receptors is central to numerous physiological processes and has profound implications for pathological conditions such as Parkinson’s disease, schizophrenia, addiction, and mood disorders. Dopamine receptors can also modulate the immune response in various peripheral tissues and organs. Immune cells, such as T cells, B cells, and macrophages, express dopamine receptors. This emerging understanding of the interplay between dopamine, dopamine receptors, and peripheral immunity highlights the multifaceted roles of this neurotransmitter in both the brain and the body, with potential implications for the development of novel therapeutic strategies for various neurological, neuropsychiatric, and immune-related disorders.

Prof. Dr. Habibeh Khoshbouei
Guest Editor

Manuscript Submission Information

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Keywords

  • neuroscience
  • dopamine
  • dopamine receptors
  • peripheral immunity

Published Papers (1 paper)

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Research

13 pages, 961 KiB  
Article
Amphetamine Exposure during Embryogenesis Alters Expression and Function of Tyrosine Hydroxylase and the Vesicular Monoamine Transporter in Adult C. elegans
by Tao Ke, Katie E. Poquette, Sophia L. Amro Gazze and Lucia Carvelli
Int. J. Mol. Sci. 2024, 25(8), 4219; https://doi.org/10.3390/ijms25084219 - 11 Apr 2024
Viewed by 293
Abstract
Amphetamines (Amph) are psychostimulants broadly used as physical and cognitive enhancers. However, the long-term effects of prenatal exposure to Amph have been poorly investigated. Here, we show that continuous exposure to Amph during early development induces long-lasting changes in histone methylation at the [...] Read more.
Amphetamines (Amph) are psychostimulants broadly used as physical and cognitive enhancers. However, the long-term effects of prenatal exposure to Amph have been poorly investigated. Here, we show that continuous exposure to Amph during early development induces long-lasting changes in histone methylation at the C. elegans tyrosine hydroxylase (TH) homolog cat-2 and the vesicular monoamine transporter (VMAT) homologue cat-1 genes. These Amph-induced histone modifications are correlated with enhanced expression and function of CAT-2/TH and higher levels of dopamine, but decreased expression of CAT-1/VMAT in adult animals. Moreover, while adult animals pre-exposed to Amph do not show obvious behavioral defects, when challenged with Amph they exhibit Amph hypersensitivity, which is associated with a rapid increase in cat-2/TH mRNA. Because C. elegans has helped reveal neuronal and epigenetic mechanisms that are shared among animals as diverse as roundworms and humans, and because of the evolutionary conservation of the dopaminergic response to psychostimulants, data collected in this study could help us to identify the mechanisms through which Amph induces long-lasting physiological and behavioral changes in mammals. Full article
(This article belongs to the Special Issue Cellular and Molecular Studies of Dopamine and Its Receptors)
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