Molecular Research on Skeletal Muscle Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 15 June 2024 | Viewed by 1477
Special Issue Editors
Interests: skeletal muscle diseases; tropomyosin mutations; contractile dysfunction; therapeutic approaches
Special Issues, Collections and Topics in MDPI journals
Interests: congenital myopathy; molecular mechanisms of muscle contraction; muscle proteins; polarized microfluorimetry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The elucidation of the molecular mechanisms of muscle contraction in health and diseases is one of the priority tasks of biology. The disturbance of actin–myosin interaction and its regulation, underlying muscle contraction, is the cause of severe diseases that extremely negatively affect the quality of human life. At present, the molecular mechanisms of the onset of muscle weakness and atrophy, which is typical for most skeletal muscle diseases, are completely insufficiently studied. Therapeutic approaches to eliminate muscle weakness and restore the contractile function of skeletal muscles have not been developed and are still limited to orthopedic correction, exercises, and physiotherapy. Understanding the primary causes of muscle weakness is necessary for the early diagnosis and prognosis of the disease, as well as for the development of therapeutic approaches to rehabilitate contractile function. The purpose of this Special Issue is to summarize new data on the functional consequences of mutant toxic proteins and pathological processes in the sarcomere, to elucidate the relationship between pathological events occuring in the sarcomere and disease phenotypes, and to identify targets for action in order to correct muscle dysfunction.
Topics include, but are not limited to, the following:
- Study of the structural and functional consequences of the mutations associated with various skeletal muscle diseases;
- Identification of impaired protein–protein interactions and analyses of further pathways of contractile dysfunction;
- Identification of targets for restoring normal skeletal muscle function;
- Searching for and testing of potential drugs for the treatment of muscle diseases.
Authors are invited to contribute to this Special Issue, which will publish priority research clarifying the molecular mechanisms of skeletal muscle dysfunction.
Dr. Olga Karpicheva
Prof. Dr. Yurii Borovikov
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- muscle contraction
- calcium regulation
- desease-causing mutations
- cross-bridge cycling and kinetics
- thin filament
- ATPase activity
- actin–myosin interaction
- therapeutic approaches
