Oxidative Stress and Inflammation in Parkinson’s Disease and Mood Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 4208
Special Issue Editors
Interests: cognition; depression; anxiety; DSCAM; GABA; COX-2; mGluRs
Special Issues, Collections and Topics in MDPI journals
Interests: depression; mental disorders; glutamate transmission; glutamate receptors; epigenetics; animal models of depression
Special Issue Information
Dear Colleagues,
The involvement of inflammation and oxidative stress in the pathogenesis of neurological and psychiatric diseases, including Parkinson's disease and mood disorders, has been demonstrated. Mediators of the immune response (e.g., TNF-α, IL-1 and IL-6) can directly cause neuronal toxicity. They can cross the blood–brain barrier, but are also produced by immunocompetent cells (e.g., glial and microglia cells) in the CNS. Pro-inflammatory factors are important communication components between the immune, neurotransmitter and (neuro)endocrine systems. Cytokines are critical modulators of neurotransmitter turnover, including key monoamines (serotonin, norepinephrine, glutamate or dopamine) in mood regulation. In addition, they can induce oxidative processes. Disruption of the pro-oxidant–antioxidant balance in a cell leads to the disruption of its structure and function and ultimately to cell death.
The comorbidity of depression with Parkinson's disease has been documented. PD symptoms are caused by an approximate 50% loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), leading to a reduction in dopamine levels of about 80% in the striatum. However, the onset of the disease is unknown. Paying more attention to inflammatory and oxidative processes may be vital to understanding the pathophysiology of these diseases. We invite all researchers working on this important topic to present their research and thoughts.
Dr. Katarzyna Stachowicz
Dr. Magdalena Sowa-Kućma
Guest Editors
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Keywords
- oxidative stress
- inflammation
- Parkinson’s disease
- mood disorders
- depression
- mechanisms of depression
- cytokines
- animal models
- human study
