Molecular Mechanism of pH Regulation: From Physiology to Pathology 2.0
Deadline for manuscript submissions: 30 June 2024 | Viewed by 160
Interests: pH regulation; acid/base disturbance; metabolic acidosis; sodium-bicarbonate transporter; brain acidosis; acidosis in cancer; structure-function of acid/base transporter
Special Issues, Collections and Topics in MDPI journals
pH is an important biological factor that regulates cell function. Hydrogen ions interact with proteins and change their structure and function, resulting in modified cellular processes. Maintaining a normal pH is frequently challenged under both physiological and pathological conditions. For example, pH decreases when metabolic activity increases during heavy exercise or when blood supply is inefficient in ischemia. Typically, acidification inhibits cellular activity, such that severe acidification is deleterious to normal cells and causes cell death. On the other hand, acidification can be adversely beneficial under some pathological conditions. Cancer cells thrive in acidic microenvironments and undergo adaptations to promote survival and proliferation. The effects of pH abnormalities on physiology and relevant diseases have been studied over the past decades. This Special Issue focuses on the current understanding of pH regulation in various model systems and/or its involvement in diseases. The topic is open to original studies, reviews, and new methodologies, ranging from the molecular and cellular level to integrated organ systems.
Dr. Inyeong Choi
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- pH regulation
- acid base transporter
- acid base disturbance
- intracellular pH