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Molecular Basis of Aging Brain in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 544

Special Issue Editor


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Guest Editor
Master’s and Doctoral Program in Biology, Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan
Interests: microglia; astrocytes; border-associated macrophages (BAMs)/CNS-associated macrophages (CAMs); aging; blood–brain barrier (BBB); cerebrospinal fluid (CSF); neuroinflammation; developmental disorder; psychiatric disorder

Special Issue Information

Dear Colleagues,

Brain aging is a physiological phenomenon that affects a variety of processes, ranging from neural and glial cell functions to higher brain functions. Research aimed at understanding the complexity of brain aging has made substantial progress over the past several decades. To date, the aging- and neurodegeneration-related alterations in brain morphology and functions have been extensively clarified. On the other hand, a number of fundamental questions related to the molecular mechanisms of brain aging have not been elucidated. Here, we invite papers that explore the key questions regarding the molecular and cellular mechanisms of brain aging, including the following topics:

  • How do functional and structural abnormalities occur in neurons and glia with aging?
  • How does the interaction between neurons and glial cells change during aging?
  • How is the regulation of blood–brain barrier maintenance and disruption influenced by aging?
  • What is the relevance of the dysfunction associated with brain aging to neurological disorders?

We welcome submissions of various types of papers, including research articles, short communications, and reviews. We would be delighted to engage in discussions on the latest developments in the field of brain aging in this Special Issue.

Dr. Fuminori Tsuruta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (1 paper)

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Review

12 pages, 902 KiB  
Review
Molecular Basis of Neuronal and Microglial States in the Aging Brain and Impact on Cerebral Blood Vessels
by Chihiro Maeda and Fuminori Tsuruta
Int. J. Mol. Sci. 2024, 25(8), 4443; https://doi.org/10.3390/ijms25084443 - 18 Apr 2024
Viewed by 302
Abstract
Brain aging causes a wide variety of changes at the molecular and cellular levels, leading to the decline of cognitive functions and increased vulnerability to neurodegenerative disorders. The research aimed at understanding the aging of the brain has made much progress in recent [...] Read more.
Brain aging causes a wide variety of changes at the molecular and cellular levels, leading to the decline of cognitive functions and increased vulnerability to neurodegenerative disorders. The research aimed at understanding the aging of the brain has made much progress in recent decades. Technological innovations such as single-cell RNA-sequencing (scRNA-seq), proteomic analyses, and spatial transcriptomic analyses have facilitated the research on the dynamic changes occurring within neurons, glia, and other cells along with their impacts on intercellular communication during aging. In this review, we introduce recent trends of how neurons and glia change during aging and discuss the impact on the brain microenvironment such as the blood-brain barrier (BBB). Full article
(This article belongs to the Special Issue Molecular Basis of Aging Brain in Health and Disease)
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