Interactions between the Environment and the Intestinal Epithelium: Gut Barrier Function and Inflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 1175
Special Issue Editors
Interests: intestinal barrier function; gut microbiota; mucosal immunology; inflammatory bowel disease; IBD pathways (Nod2, autophagy, endoplasmic reticulum stress, Th17)
Special Issues, Collections and Topics in MDPI journals
2. Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, F-31300 Toulouse, France
Interests: inflammatory bowel disease; translational research; nutrition; cystic fibrosis; intestinal polyposis; endoscopy; gut microbiota
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The gastrointestinal tract is a complex interface between the immune system and its external environment. It establishes a dynamic barrier that enables dietary nutrients to be absorbed and harmful compounds to be excluded from the intestinal lumen, while permitting the sampling of luminal antigens as part of immune surveillance. The ability to control the intake of nutrients across the mucosa and protect it from damage of harmful substances contained in the lumen is defined as the intestinal barrier function (IBF). The IBF comprises epithelial cells, as well as immune cells and their secretions. Gut microbiota participate in regulating the integrity and function of the intestinal barrier by maintaining a homeostatic balance. Pathogens, xenobiotics and diet can disrupt the IBF, which causes tissue damage and systemic inflammation.
Numerous human diseases, including intestinal pathologies (inflammatory bowel diseases, irritable bowel syndrome, celiac disease, etc.), as well as extra-intestinal pathologies (metabolic, infectious, neurologic, and cardiovascular), are linked to an impairment of the IBF, leading to the development of “leaky gut syndrome”. Therefore, identifying and understanding the mechanisms by which environmental factors destabilize the IBF, thus promoting disease development, represent an important research direction for the diagnosis and treatment of various intestinal and extra-intestinal diseases.
Here, we invite experts to contribute to this Special Issue with original research or review articles, investigating the components of the environment that may have a beneficial or detrimental impact on the IBF. Since IJMS is a molecular sciences journal, purely clinical studies will not suitable. However, clinical or pure model submissions with biomolecular experiments are welcomed.
Dr. Frédérick Barreau
Prof. Dr. Emmanuel Mas
Guest Editors
Manuscript Submission Information
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Keywords
- advances on the environmental factors including nano- and micro-particles and pesticides
- food additives
- microbiota metabolites with anti- or pro-inflammatory properties
- intestinal permeability
- intestinal stem cells
