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Stem Cells: Physiological, Cellular and Molecular Mechanisms
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Stem Cells: Physiological, Cellular and Molecular Mechanisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1013

Special Issue Editor

Dr. Elizabeth A. Blaber

E-Mail Website
Guest Editor
Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
Interests: stem cells; regeneration; tissue engineering; spaceflight; iPSCs; multi-organ microphysiological systems

Special Issue Information

Dear Colleagues,

Advances in stem cell biology over the last decade have dramatically increased our understand of the molecular, cellular, and physiological mechanisms driving stem cell function. However, our understanding of how stem cell populations contribute to health and disease is still an area of active investigation. Additionally, the molecular mechanisms that regulate the maintenance of pluri- or multi-potency during aging and disease progression are vital to the use of stem cells in regenerative medicine. In this Special Issue ‘Stem Cells: Physiological, Cellular and Molecular Mechanisms’, we specifically invite the submission of studies that investigate the molecular regulation of stem cell function, including genetic, epigenetic, proteomic, and metabolic analyses. We also invite the submission of studies that investigate cellular interactions between stem cell or differentiated cell populations, including those within the stem cell niche microenvironment, and the impact of these interactions on overall physiological function. All stem cell types, iPSCs, somatic or embryonic stem cells are of interest in this Special Issue.

Dr. Elizabeth A. Blaber
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cell function
  • iPSC
  • embryonic stem cells
  • somatic stem cells
  • pluripotency
  • differentiation
  • physiology
  • microenvironment
  • molecular regulation
  • cellular interactions

Published Papers (2 papers)

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Research

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9 pages, 1763 KiB  
Communication
Apoptosis in Postmortal Tissues of Goat Spinal Cords and Survival of Resident Neural Progenitors
by Andrey Mikhailov and Yoshiyuki Sankai
Int. J. Mol. Sci. 2024, 25(9), 4683; https://doi.org/10.3390/ijms25094683 - 25 Apr 2024
Viewed by 161
Abstract
Growing demand for therapeutic tissue repair recurrently focusses scientists’ attention on critical assessment of postmortal collection of live cells, especially stem cells. Our study aimed to assess the survival of neuronal progenitors in postmortal spinal cord and their differentiation potential. Postmortal samples of [...] Read more.
Growing demand for therapeutic tissue repair recurrently focusses scientists’ attention on critical assessment of postmortal collection of live cells, especially stem cells. Our study aimed to assess the survival of neuronal progenitors in postmortal spinal cord and their differentiation potential. Postmortal samples of spinal cords were obtained from human-sized animals (goats) at 6, 12, 24, 36, and 54 h after slaughter. Samples were studied by immunohistology, differentiation assay, Western blot and flow cytometry for the presence and location of GD2-positive neural progenitors and their susceptibility to cell death. TUNEL staining of the goat spinal cord samples over 6–54 h postmortem revealed no difference in the number of positive cells per cross-section. Many TUNEL-positive cells were located in the gray commissure around the central canal of the spinal cord; no increase in TUNEL-positive cells was recorded in either posterior or anterior horns of the gray matter where many GD2-positive neural progenitors can be found. The active caspase 3 amount as measured by Western blot at the same intervals was moderately increasing over time. Neuronal cells were enriched by magnetic separation with antibodies against CD24; among them, the GD2-positive neural progenitor subpopulation did not overlap with apoptotic cells having high pan-caspase activity. Apoptotic cell death events are relatively rare in postmortal spinal cords and are not increased in areas of the neural progenitor cell’s location, within measured postmortal intervals, or among the CD24/GD2-positive cells. Data from our study suggest postmortal spinal cords as a valuable source for harvesting highly viable allogenic neural progenitor cells. Full article
(This article belongs to the Special Issue Stem Cells: Physiological, Cellular and Molecular Mechanisms)

Review

Jump to: Research

13 pages, 1460 KiB  
Review
Dental Stem Cells and Lipopolysaccharides: A Concise Review
by Beatriz A. Rodas-Junco, Sandra E. Hernández-Solís, Angelica A. Serralta-Interian and Florencio Rueda-Gordillo
Int. J. Mol. Sci. 2024, 25(8), 4338; https://doi.org/10.3390/ijms25084338 - 14 Apr 2024
Viewed by 422
Abstract
Dental tissue stem cells (DTSCs) are well known for their multipotent capacity and regenerative potential. They also play an important role in the immune response of inflammatory processes derived from caries lesions, periodontitis, and gingivitis. These oral diseases are triggered by toxins known [...] Read more.
Dental tissue stem cells (DTSCs) are well known for their multipotent capacity and regenerative potential. They also play an important role in the immune response of inflammatory processes derived from caries lesions, periodontitis, and gingivitis. These oral diseases are triggered by toxins known as lipopolysaccharides (LPS) produced by gram-negative bacteria. LPS present molecular patterns associated with pathogens and are recognized by Toll-like receptors (TLRs) in dental stem cells. In this review, we describe the effect of LPS on the biological behavior of DTSCs. We also focus on the molecular sensors, signaling pathways, and emerging players participating in the interaction of DTSCs with lipopolysaccharides. Although the scientific advances generated provide an understanding of the immunomodulatory potential of DTSCs, there are still new reflections to explore with regard to their clinical application in the treatment of oral inflammatory diseases. Full article
(This article belongs to the Special Issue Stem Cells: Physiological, Cellular and Molecular Mechanisms)
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