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Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes
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Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 2325

Special Issue Editor

Dr. Daniela Miricescu

E-Mail Website
Guest Editor
Department of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: PI3K/AKT/mTOR; oxidative stress; breast cancer; burns; colorectal cancer; PLGA nanoparticles; platelet rich plasma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Malignant neoplasms, characterized by successive genetic and epigenetic alterations of healthy cells, are one of the leading causes of death within the adult population. Usually, most cancers emerge at the epithelial cells, leading to organ-specific carcinomas affecting skin, liver, lung, breast, or pancreas. Since oncogenic mutations induce gene overexpression and subsequently cause protein dysregulation, the PI3K/AKT/mTOR, TGF-β family, Ras/Raf/MEK/ERK, and the Wnt/β-catenin signaling pathway dysregulations are correlated with the proliferation, angiogenesis, invasion, and metastasis of cancer cells. Therefore, inhibitors targeting these pathways are considered as novel therapeutic candidates for the development of potential anticancer agents.

We cordially invite submissions of original research and comprehensive review articles for inclusion in this Special Issue.

This Special Issue is overseen by Dr. Daniela Miricescu with the assistance of Dr. Constantin Stefani ( Department of Family Medicine and Clinical Base, Dr. Carol Davila Central Military Emergency University Hospital).

Dr. Daniela Miricescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • epithelial cells
  • oncogenic mutations
  • PI3K/AKT/mTOR
  • TGF-β
  • Ras/Raf/MEK/ERK
  • Wnt/β-catenin
  • angiogenesis
  • invasion
  • metastasis
  • inhibitors

Published Papers (1 paper)

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Review

26 pages, 1785 KiB  
Review
Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer
by Diana-Theodora Morgos, Constantin Stefani, Daniela Miricescu, Maria Greabu, Silviu Stanciu, Silvia Nica, Iulia-Ioana Stanescu-Spinu, Daniela Gabriela Balan, Andra-Elena Balcangiu-Stroescu, Elena-Claudia Coculescu, Dragos-Eugen Georgescu and Remus Iulian Nica
Int. J. Mol. Sci. 2024, 25(3), 1848; https://doi.org/10.3390/ijms25031848 - 03 Feb 2024
Viewed by 2018
Abstract
Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year. Helicobacter pylori represents the main risk factor, being responsible for 78% of the cases. Increased amounts of salt, pickled food, red meat, alcohol, [...] Read more.
Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year. Helicobacter pylori represents the main risk factor, being responsible for 78% of the cases. Increased amounts of salt, pickled food, red meat, alcohol, smoked food, and refined sugars negatively affect the stomach wall, contributing to GC development. Several gene mutations, including PIK3CA, TP53, ARID1A, CDH1, Ras, Raf, and ERBB3 are encountered in GC pathogenesis, leading to phosphatidylinositol 3-kinase (PI3K) protein kinase B (AKT)/mammalian target of rapamycin (mTOR)—PI3K/AKT/mTOR—and mitogen-activated protein kinase (MAPK) signaling pathway activation and promoting tumoral activity. Helicobacter pylori, growth factors, cytokines, hormones, and oxidative stress also activate both pathways, enhancing GC development. In clinical trials, promising results have come from monoclonal antibodies such as trastuzumab and ramucirumab. Dual inhibitors targeting the PI3K/AKT/mTOR and MAPK signaling pathways were used in vitro studies, also with promising results. The main aim of this review is to present GC incidence and risk factors and the dysregulations of the two protein kinase complexes together with their specific inhibitors. Full article
(This article belongs to the Special Issue Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes)
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