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Current Research on Diabetes and Metabolic Syndrome
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Current Research on Diabetes and Metabolic Syndrome

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 1802

Special Issue Editor

Prof. Dr. Natalija Filipović

E-Mail Website
Guest Editor
Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Šoltanska 2, 21000 Split, Croatia
Interests: microvascular and macrovascular complications of diabetes; diabetic nephropathy; renal physiology and pathology; gene expression during embryonic and foetal development; kidneys and urinary system
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes and metabolic syndrome are among the leading public health problems in modern society, with increasing incidence. According to some estimations, over a billion people globally are affected by metabolic syndrome, while the International Diabetes Federation projects that the number of adults with diabetes worldwide will increase to 693 million by 2045. Despite the increase in the number of studies focused on these issues, there are still many gaps in our knowledge about the pathogenesis of metabolic syndrome and diabetic complications. In addition, current therapeutic approaches are limited in terms of their effectiveness. A large number of patients do not respond to specific therapeutic approaches, and results are often limited. Moreover, new promising strategies to prevent DM complications appear to carry serious side effects (ketoacidosis, increased risk of amputation, and genitourinary system infections). Therefore, new prevention and therapeutic strategies are needed, based on the understanding brought about by new scientific research. Therefore, we invite researchers to submit original papers or review articles that contribute to our knowledge about the pathogenesis of diabetic complications and metabolic syndrome, and/or reveal potential new strategies for their prevention and treatment.

Prof. Dr. Natalija Filipović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes
  • metabolic syndrome
  • obesity
  • insulin resistance
  • diabetic neuropathy
  • diabetic kidney disease
  • diabetic retinopathy
  • coronary heart disease
  • cardiomyopathy
  • cerebrovascular disease
  • peripheral artery disease

Published Papers (2 papers)

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Research

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11 pages, 502 KiB  
Article
Circulating Interleukins-33 and -37 and Their Associations with Metabolic Syndrome in Arab Adults
by Osama E. Amer, Shaun Sabico, Malak N. K. Khattak, Abdullah M. Alnaami, Gamal M. Saadawy and Nasser M. Al-Daghri
Int. J. Mol. Sci. 2024, 25(2), 699; https://doi.org/10.3390/ijms25020699 - 05 Jan 2024
Viewed by 659
Abstract
Interleukins (ILs) are a group of cytokines known to have immunomodulatory effects; they include ILs–33 and –37 whose emerging roles in the pathogenesis of metabolic syndrome (MetS) remain under investigated. In this study, we compared circulating IL–33 and IL–37 in Arab adults with [...] Read more.
Interleukins (ILs) are a group of cytokines known to have immunomodulatory effects; they include ILs–33 and –37 whose emerging roles in the pathogenesis of metabolic syndrome (MetS) remain under investigated. In this study, we compared circulating IL–33 and IL–37 in Arab adults with and without MetS to determine its associations with MetS components. A total of 417 Saudi participants (151 males, 266 females; mean age ± SD 41.3 ± 9.0 years; mean body mass index ± SD 30.7 ± 6.3 kg/m2) were enrolled and screened for MetS using the ATP III criteria. Anthropometrics and fasting blood samples were taken for the assessment of fasting glucose and lipids. Circulating levels of IL–33 and IL–37 were measured using commercially available assays. The results showed higher levels of serum IL–33 and IL–37 in participants with MetS than those without (IL-33, 3.34 3.42 (2.3–3.9) vs. (1–3.9), p = 0.057; IL-37, 5.1 (2.2–8.3) vs. 2.9 (2.1–6.1), p = 0.01). Additionally, having elevated levels of IL–33 was a risk factor for hypertension, low HDL-c, and hypertriglyceridemia. A stratification of the participants according to sex showed that males had higher IL-33 levels than females [3.7 (3.0–4.1) vs. 3.15 (1.4–3.8), p < 0.001], while females had higher levels of IL–37 than males [3.01 (2.2–7.0) vs. 2.9 (2.1–5.6), p = 0.06]. In conclusion, the presence of MetS substantially alters the expression of ILs–33 and -37. IL-33 in particular can be potentially used as a therapeutic target to prevent MetS progression. Longitudinal and interventional studies are warranted to confirm present findings. Full article
(This article belongs to the Special Issue Current Research on Diabetes and Metabolic Syndrome)
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Review

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19 pages, 1130 KiB  
Review
Metabolic Crossroads: Unveiling the Complex Interactions between Obstructive Sleep Apnoea and Metabolic Syndrome
by Aisling Heffernan, Darko Duplancic, Marko Kumric, Tina Ticinovic Kurir and Josko Bozic
Int. J. Mol. Sci. 2024, 25(6), 3243; https://doi.org/10.3390/ijms25063243 - 13 Mar 2024
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Abstract
Obstructive sleep apnoea (OSA) and components of metabolic syndrome (MetS) are inextricably connected. Considering the increasing burden of MetS and OSA, in the present review, we aimed to collate and summarise the potential pathophysiological mechanisms linking these pathologies. In short, obesity appears to [...] Read more.
Obstructive sleep apnoea (OSA) and components of metabolic syndrome (MetS) are inextricably connected. Considering the increasing burden of MetS and OSA, in the present review, we aimed to collate and summarise the potential pathophysiological mechanisms linking these pathologies. In short, obesity appears to promote OSA development via multiple pathways, some of which are not directly related to mass but rather to metabolic complications of obesity. Simultaneously, OSA promotes weight gain through central mechanisms. On the other hand, diabetes mellitus contributes to OSA pathophysiology mainly through effects on peripheral nerves and carotid body desensitization, while intermittent hypoxia and sleep fragmentation are the principal culprits in OSA-mediated diabetes. Apart from a bidirectional pathophysiological relationship, obesity and diabetes mellitus together additively increase cardiovascular risk in OSA patients. Additionally, the emergence of new drugs targeting obesity and unequivocal results of the available studies underscore the need for further exploration of the mechanisms linking MetS and OSA, all with the aim of improving outcomes in these patients. Full article
(This article belongs to the Special Issue Current Research on Diabetes and Metabolic Syndrome)
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