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Progression of Allergy and Immune Response
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Progression of Allergy and Immune Response

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 10 July 2024 | Viewed by 2088

Special Issue Editors

Dr. Francis Palomares-Jerez

E-Mail Website
Guest Editor
Department of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, Av. Sanchez Pizjuan s/n, 41009 Seville, Spain
Interests: biophysic; immunology; immunometabolism; inflammation; immunotherapy; nanosystem
Prof. Dr. Soledad Lopez-Enriquez

E-Mail Website
Guest Editor
Department of Medical Biochemistry, Molecular Biology, Immunology School of Medicine, Universidad de Sevilla, Av. Sanchez Pizjuan s/n, 41009 Seville, Spain
Interests: food; nutrients; immunology; innate and adaptative response; immunometabolism; signaling pathways; flow cytometry; cell culture; allergy; allergic rhinitis; chronic rhinosinusitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Allergies are a common, chronic condition in which the immune system reacts abnormally to substances, such as pollen, dust mites, pet dander, food, insect venom, and medications, that are normally harmless for everyone else. These can trigger allergic reactions in susceptible individuals. In fact, these reactions are increasing worldwide. The main objective of this Special Issue is covering the information about the tools that are available for the diagnosis and treatment of allergies. This Issue will include manuscripts that focus on the identifications of biomarkers that can be used as valuable parameters of diagnosis and treatment efficacy monitoring and the identification of therapeutic targets and new therapeutic approaches for allergies. The presented materials are the result of the international scientific cooperation of experts specializing in these issues. The content may be useful for clinical results to help in the diagnosis and treatment of allergies.

Dr. Francis Palomares-Jerez
Prof. Dr. Soledad Lopez-Enriquez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy
  • nutraceuticals
  • diagnostic and treatment
  • immunity

Published Papers (2 papers)

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Research

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15 pages, 2206 KiB  
Article
The Plight of the Metabolite: Oxidative Stress and Tear Film Destabilisation Evident in Ocular Allergy Sufferers across Seasons in Victoria, Australia
by Esrin Aydin, Damien L. Callahan, Luke Chong, Serap Azizoglu, Moneisha Gokhale and Cenk Suphioglu
Int. J. Mol. Sci. 2024, 25(7), 4019; https://doi.org/10.3390/ijms25074019 - 04 Apr 2024
Viewed by 445
Abstract
Ocular allergy (OA) is characterised by ocular surface itchiness, redness, and inflammation in response to allergen exposure. The primary aim of this study was to assess differences in the human tear metabolome and lipidome between OA and healthy controls (HCs) across peak allergy [...] Read more.
Ocular allergy (OA) is characterised by ocular surface itchiness, redness, and inflammation in response to allergen exposure. The primary aim of this study was to assess differences in the human tear metabolome and lipidome between OA and healthy controls (HCs) across peak allergy (spring–summer) and off-peak (autumn–winter) seasons in Victoria, Australia. A total of 19 participants (14 OA, 5 HCs) aged 18–45 were recruited and grouped by allergy questionnaire score. Metabolites and lipids from tear samples were analysed using mass spectrometry. Data were analysed using TraceFinder and Metaboanalyst. Metabolomics analysis showed 12 differentially expressed (DE) metabolites between those with OA and the HCs during the peak allergy season, and 24 DE metabolites were found in the off-peak season. The expression of niacinamide was upregulated in OA sufferers vs. HCs across both seasons (p ≤ 0.05). A total of 6 DE lipids were DE between those with OA and the HCs during the peak season, and 24 were DE in the off-peak season. Dysregulated metabolites affected oxidative stress, inflammation, and homeostasis across seasons, suggesting a link between OA-associated itch and ocular surface damage via eye rubbing. Tear lipidome changes were minimal between but suggested tear film destabilisation and thinning. Such metabolipodome findings may pave new and exciting ways for effective diagnostics and therapeutics for OA sufferers in the future. Full article
(This article belongs to the Special Issue Progression of Allergy and Immune Response)
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Review

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20 pages, 616 KiB  
Review
Modulation of the Immune Response to Allergies Using Alternative Functional Foods
by Soledad López-Enríquez, Ana M. Múnera-Rodríguez, Camila Leiva-Castro, Francisco Sobrino and Francisca Palomares
Int. J. Mol. Sci. 2024, 25(1), 467; https://doi.org/10.3390/ijms25010467 - 29 Dec 2023
Viewed by 1191
Abstract
Modulation of the allergic immune response through alternative therapies is a field of study that aims to address allergic reactions differently from traditional approaches. These therapies encompass the utilization of natural functional foods, which have been observed to exert an influence on the [...] Read more.
Modulation of the allergic immune response through alternative therapies is a field of study that aims to address allergic reactions differently from traditional approaches. These therapies encompass the utilization of natural functional foods, which have been observed to exert an influence on the immune response, thus mitigating the severity of allergies. Indeed, some studies suggest that the incorporation of these nutraceuticals can regulate immune function, leading to a reduction in histamine release and subsequent alleviation of allergic symptoms. Moreover, certain herbs and dietary supplements, such as curcumin, are believed to possess anti-inflammatory properties, which may serve to moderate allergic responses. Although the results remain somewhat mixed and require further research, these alternative therapies exhibit the potential to impact the allergic immune response, thereby providing complementary options to conventional treatments. Therefore, in this review, we aim to provide an updated account of functional foods capable of modulating the immune response to allergies. In that sense, the review delves into functional foods sourced from plants (phytochemicals), animals, and marine algae. Emphasis is placed on their potential application in the treatment of allergic disorders. It also provides an overview of how these foods can be effectively utilized as functional foods. Additionally, it explores the molecular mechanisms and scientific validity of various bioactive natural compounds in the management of allergies. Full article
(This article belongs to the Special Issue Progression of Allergy and Immune Response)
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