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Novel Extracellular Vesicle-Based Therapy for Central Nervous System Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 919

Special Issue Editor


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Guest Editor
Fundación de Investigación Hospital Clínico Universitario de Valencia-INCLIVA, 46010 Valencia, Spain
Interests: extracellular vesicles; biomarker; inflammation; neurological impairment; metabolic dysfunction; intercellular and interorgan crosstalk

Special Issue Information

Dear Colleagues,

The central nervous system (CNS) plays a pivotal role in regulating bodily functions, making the study and treatment of CNS diseases a critical area of research. Extracellular vesicles, including exosomes and microvesicles, have emerged as key players in intercellular communication and the delivery of bioactive molecules. This Special Issue aims to explore the innovative use of EVs as therapeutic agents to target CNS disorders, including neurodegenerative diseases, encephalopathies, mild cognitive impairment, traumatic brain injuries, and neurological cancers.

We welcome submissions of original research manuscripts, short communications, and reviews focusing on the latest advancements in the following areas (the list is not exhaustive): the isolation and characterization of EVs, the cargo of bioactive molecules, mechanisms of action, preclinical and clinical studies, EVs from mesenchymal stem cells (MSCs) and future directions for EV-based therapies in the CNS.

Dr. Andrea Cabrera-Pastor
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • extracellular vesicles (EVs)
  • exosomes
  • therapy
  • CNS disorders
  • neuroinflammation
  • signal transduction
  • mechanism
  • interorgan crosstalk
  • biomarker
  • EVs from MSCs
  • drug delivery

Published Papers (1 paper)

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Research

15 pages, 2080 KiB  
Article
Exercise-Intervened Endothelial Progenitor Cell Exosomes Protect N2a Cells by Improving Mitochondrial Function
by Shuzhen Chen, Smara Sigdel, Harshal Sawant, Ji Bihl and Jinju Wang
Int. J. Mol. Sci. 2024, 25(2), 1148; https://doi.org/10.3390/ijms25021148 - 17 Jan 2024
Viewed by 704
Abstract
We have recently demonstrated that exosomal communication between endothelial progenitor cells (EPCs) and brain endothelial cells is compromised in hypertensive conditions, which might contribute to the poor outcomes of stroke subjects with hypertension. The present study investigated whether exercise intervention can regulate EPC–exosome [...] Read more.
We have recently demonstrated that exosomal communication between endothelial progenitor cells (EPCs) and brain endothelial cells is compromised in hypertensive conditions, which might contribute to the poor outcomes of stroke subjects with hypertension. The present study investigated whether exercise intervention can regulate EPC–exosome (EPC-EX) functions in hypertensive conditions. Bone marrow EPCs from sedentary and exercised hypertensive transgenic mice were used for generating EPC-EXs, denoted as R-EPC-EXs and R-EPC-EXET. The exosomal microRNA profile was analyzed, and EX functions were determined in a co-culture system with N2a cells challenged by angiotensin II (Ang II) plus hypoxia. EX-uptake efficiency, cellular survival ability, reactive oxygen species (ROS) production, mitochondrial membrane potential, and the expressions of cytochrome c and superoxide-generating enzyme (Nox4) were assessed. We found that (1) exercise intervention improves the uptake efficiency of EPC-EXs by N2a cells. (2) exercise intervention restores miR-27a levels in R-EPC-EXs. (3) R-EPC-EXET improved the survival ability and reduced ROS overproduction in N2a cells challenged with Ang II and hypoxia. (4) R-EPC-EXET improved the mitochondrial membrane potential and decreased cytochrome c and Nox4 levels in Ang II plus hypoxia-injured N2a cells. All these effects were significantly reduced by miR-27a inhibitor. Together, these data have demonstrated that exercise-intervened EPC-EXs improved the mitochondrial function of N2a cells in hypertensive conditions, which might be ascribed to their carried miR-27a. Full article
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